Actively Recruiting
ASHBY: Accelerated Super-Hypofractionated Breast Brachytherapy
Led by Virginia Commonwealth University · Updated on 2025-11-21
170
Participants Needed
1
Research Sites
476 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to compare any good and bad effects of giving radiation treatment for breast cancer in 3 treatments over about 2 days.
CONDITIONS
Official Title
ASHBY: Accelerated Super-Hypofractionated Breast Brachytherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female
- New diagnosis of ductal carcinoma in situ (DCIS) and/or invasive breast carcinoma confirmed by histology
- Age between 45 and 79 years at diagnosis
- Previous lumpectomy with surgical margins free of invasive tumor and DCIS as confirmed by pathology
- Tumor stage Tis, T1, or T2
- T2 tumors must be 3 cm or smaller in maximum diameter
- HER2-positive patients must receive HER2-directed therapy
- For invasive breast cancer, axillary staging must be done with negative nodes (N0), except for certain patients aged 70 or older meeting specific hormone receptor and tumor size criteria
- Ability to understand and willing to sign informed consent in English
You will not qualify if you...
- Pregnant or breastfeeding
- Active collagen-vascular disease
- Paget's disease of the breast
- History of DCIS or invasive breast cancer before the current diagnosis
- Prior radiation therapy to the breast or chest area for any condition
- Multicentric carcinoma (multiple tumor sites) in the breast
- Synchronous bilateral invasive or non-invasive breast cancer
- Surgical margins that are positive or cannot be microscopically assessed
- Excision cavity that cannot be clearly defined by the investigator
- Failure to meet required dosimetric treatment criteria
- Medical, psychological, or social conditions that may increase risk or limit adherence to study requirements
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
Research Team
M
Massey IIT Research Operations
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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