Actively Recruiting

FEMALE
ID07196033

Asian Gynecological Brachytherapy Registry in Cervical Cancer

Led by Tata Memorial Hospital ยท Updated on 2026-02-09

1000

Participants Needed

5

Research Sites

9 weeks

Total Duration

On this page

Sponsors

T

Tata Memorial Hospital

Lead Sponsor

C

Chiang Mai University, Thailand

Collaborating Sponsor

AI-Summary

What this Trial Is About

Gynecological cancer, particularly cervical cancer, is a significant health challenge in Asia, causing many deaths due to limited preventive care, screening, and cultural delays in seeking treatment. This research focuses on advanced cervical cancer patients treated with radiation and chemotherapy followed by internal radiation called brachytherapy. While advanced brachytherapy methods have shown good results in Western countries, there is a lack of data on their use and outcomes in Asian populations, leading to inconsistent treatment practices. The Asian Gynecological Brachytherapy Registry (ABGR) is a collaborative effort collecting data from multiple centers across Asia. It uses a retrospective cohort design to include patients treated over a 12-month period with different brachytherapy techniques and imaging methods. The registry also gathers information on external radiation, chemotherapy, treatment timing, patient demographics, and treatment planning variations. This comprehensive data aims to understand treatment patterns, outcomes, and factors influencing care across Asian healthcare settings. Participants' medical records will be reviewed to record the types of brachytherapy and radiation treatments used, chemotherapy doses, treatment schedules, and side effects over a three-year period. The study will measure outcomes such as local and regional cancer control, disease-free survival, and radiation-related adverse events. Data quality and patient privacy are maintained through strict protocols, and the findings will support future improvements in cervical cancer care in Asia.

CONDITIONS

Brief Title

Asian Gynecological Brachytherapy Registry in Cervical Cancer

Who Can Participate

FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients diagnosed with FIGO 2018 stage IB-IVA cervical cancer with squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma histological subtype.
  • Planned for treatment with definitive chemo-radiation and brachytherapy using X-ray, CT, CT-Ultrasound, or MRI based techniques.
Not Eligible

You will not qualify if you...

  • Neuroendocrine cancer of the cervix or other rare histology subtypes.
  • Patients with metastatic cervical cancer not planned for radical doses of pelvic radiation therapy or brachytherapy.
  • Patients undergoing postoperative radiation therapy or radiation therapy for recurrent disease.

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Monitoring

Duration - Up to 3 years

Participants who have received brachytherapy and concurrent treatments are observed to record treatment patterns, clinical outcomes, and adverse events over time.

Follow-up visits as per routine care

Trial Site Locations

Total: 5 locations

1

Tata Memorial Center

Mumbai, Maharashtra, India, 400012

Actively Recruiting

2

Gunma University

Maebashi, Japan, Japan

Not Yet Recruiting

3

Juntendo University

Tokyo, Japan, Japan

Not Yet Recruiting

4

Mahidol University

Bangkok, Thailand, Thailand

Not Yet Recruiting

5

Chiang Mai University

Chiang Mai, Thailand, Thailand

Not Yet Recruiting

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Research Team

D

Dr. Supriya Chopra

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Transitioning India to advanced image based adaptive brachytherapy: a national impact analysis of upgrading National Cancer Grid cervix cancer guidelines.

Varsha Hande, Supriya Chopra, Alfredo Polo...

https://pubmed.ncbi.nlm.nih.gov/37694176

Preliminary results of conformal computed tomography (CT)-based intracavitary brachytherapy (ICBT) for locally advanced cervical cancer: a single institution's experience.

Ekkasit Tharavichitkul, Somvilai Mayurasakorn, Vicharn Lorvidhaya...

https://pubmed.ncbi.nlm.nih.gov/21952319

Standard Chemoradiation and Conventional Brachytherapy for Locally Advanced Cervical Cancer: Is It Still Applicable in the Era of Magnetic Resonance-Based Brachytherapy?

Prachi Mittal, Supriya Chopra, Sidharth Pant...

https://pubmed.ncbi.nlm.nih.gov/30085892

Magnetic Resonance Image Guided Adaptive Brachytherapy in Locally Advanced Cervical Cancer: An Experience From a Tertiary Cancer Center in a Low and Middle Income Countries Setting.

Umesh Mahantshetty, Rahul Krishnatry, Vinod Hande...

https://pubmed.ncbi.nlm.nih.gov/29280456

An Asian multi-national multi-institutional retrospective study comparing intracavitary versus the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical carcinoma.

Naoya Murakami, Ken Ando, Masumi Murata...

https://pubmed.ncbi.nlm.nih.gov/35446962

MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.

Richard Pรถtter, Kari Tanderup, Maximilian Paul Schmid...

https://pubmed.ncbi.nlm.nih.gov/33794207

Preliminary results of MRI-guided brachytherapy in cervical carcinoma: the Chiangmai University experience.

Ekkasit Tharavichitkul, Chate Sivasomboon, Somsak Wanwilairat...

https://pubmed.ncbi.nlm.nih.gov/22277978

Survival outcome of cervical cancer patients treated by image-guided brachytherapy: a 'real world' single center experience in Thailand from 2008 to 2018.

Ekkasit Tharavichitkul, Bongkot Jia-Mahasap, Pooriwat Muangwong...

https://pubmed.ncbi.nlm.nih.gov/35719089

Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative.

Deependra Singh, Jerome Vignat, Valentina Lorenzoni...

https://pubmed.ncbi.nlm.nih.gov/36528031

Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.

Maximilian P Schmid, Jacob C Lindegaard, Umesh Mahantshetty...

https://pubmed.ncbi.nlm.nih.gov/36599120