Actively Recruiting
Asiaticoside for Treating Overweight/Obesity
Led by Shanghai Zhongshan Hospital · Updated on 2025-12-24
30
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Centella asiatica is a traditional herbal medicine widely used in China and Southeast Asia for treating various conditions. Preclinical studies have shown that madecassic acid glycosides, including asiaticoside and madecassoside, can significantly reduce body weight gain, adipose tissue mass, and serum triglyceride levels in high-fat diet-induced obese mice. These compounds also improve hepatic steatosis and insulin resistance. This exploratory, interventional study aims to evaluate the clinical efficacy of orally administered asiaticoside tablets in adults with overweight or obesity.
CONDITIONS
Official Title
Asiaticoside for Treating Overweight/Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older, male or female
- Overweight or obesity with a body mass index (BMI) of 24.0-45.0 kg/m²
- Able and willing to provide written informed consent
You will not qualify if you...
- Active pulmonary tuberculosis, malignant tumors, HIV infection, or other severe infectious or immunocompromising conditions
- Severe liver injury (AST or ALT > 3 times the upper limit of normal) or severe kidney dysfunction (eGFR < 30 mL/min/1.73 m²)
- Severe cardiovascular disease, including angina, heart attack, or stroke within the past 6 months
- Severe gastrointestinal disorders or gastrointestinal surgery within the past year
- Secondary causes of obesity such as Cushing's syndrome, primary hypothyroidism, hypothalamic obesity, acromegaly, or drug-induced obesity
- Current use of other anti-obesity treatments, previous bariatric surgery, or more than 5% body weight loss in the past 3 months
- Current smoker or habitual smoker within the past 3 months
- Diagnosis of type 1 or type 2 diabetes or current use of hypoglycemic medications
- Pregnancy, planning pregnancy, or breastfeeding
- Unable to complete 3-month follow-up due to health or relocation
- Participation in any clinical study within the past 4 weeks
- Other conditions deemed unsuitable by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
J
Jingjing JIANG, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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