Actively Recruiting
Standardization According to GINA 2025 Recommendations for the Treatment, Management, and Follow-up of Acute Asthma Attacks: Observational, Multicenter Cohort Study
Led by Meyer Children's Hospital IRCCS · Updated on 2026-02-17
500
Participants Needed
2
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the management and treatment of acute asthma attacks in children aged 6 to 17 years presenting to emergency departments. It compares clinical outcomes before and after implementing updated guidelines based on the 2025 Global Initiative for Asthma (GINA) recommendations. The study is observational and multicenter, focusing on improving care quality through education of medical and nursing staff. The study includes two groups: a pre-intervention period from October 2024 to May 2025 where patients received standard care, and a post-intervention period from October 2025 to May 2026 following an educational program for emergency staff. This program involved lectures, clinical simulations, case discussions, and updated treatment flowcharts to guide diagnosis and therapy consistent with GINA 2025 guidelines. Participants are observed during their emergency department visits with assessments of diagnosis accuracy, drug administration timing and dosage, follow-up care at discharge, and use of additional drugs when needed. Researchers track changes across the two periods over about nine months. Outcomes include how care aligns with guidelines and incidence of asthma exacerbations. No investigational treatments are given, and data collection focuses on real-world clinical practice and outcomes.
CONDITIONS
Brief Title
ASMact: Study on Management of Bronchial Asthma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 6 and 17 years
- Presentation to the emergency department with a diagnosis of acute asthma exacerbation
- Evaluation in the emergency department of one of the participating centers during the study periods
You will not qualify if you...
- Age less than 6 years or greater than 17 years
- Diagnosis other than acute asthma exacerbation
- Incomplete or missing clinical data
- Patients transferred from other hospitals already treated for the same episode
- History of allergy to any drugs used in the protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - October 2024 to May 2025
Participants presenting with an acute asthma exacerbation are observed during the pre-intervention period receiving standard care according to local clinical practice.
Visits occur as part of routine emergency department care
Duration - October 2025 to May 2026
Participants presenting with an acute asthma exacerbation are observed during the post-intervention period after emergency department staff received a structured educational intervention based on updated asthma guidelines.
Visits occur as part of routine emergency department care
Trial Site Locations
Total: 2 locations
1
Arcispedale S. Anna
Ferrara, FE, Italy, 44124
Actively Recruiting
2
Meyer Children's Hospital IRCCS, Firenze
Florence, Italy, 50134
Actively Recruiting
Research Team
G
Grazia Fenu
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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