Actively Recruiting
Aspirin Discontinuation in High-Risk Pregnant Women of Preeclampsia
Led by FANG HE · Updated on 2024-07-03
1800
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Low-dose aspirin (LDA) is considered to be the most effective agent to prevent preeclampsia (PE). At present, there is little exploration about the timing of aspirin discontinuation. Most international guidelines default until 36 weeks of gestation or delivery. China Guideline (2020) recommended that aspirin should be preventively used until 26-28 weeks of gestation, but there was little direct evidence. According to the two-stage theory, placental dysplasia before 28 weeks of gestation is the key to developing PE, the significance of aspirin use after 28 weeks of gestation is debatable. If aspirin discontinuation at 28 weeks of gestation is proven to be feasible for preventing preterm PE, it will not only reduce the risk of Perinatal Haemorrhage but also save medical expenses.
CONDITIONS
Official Title
Aspirin Discontinuation in High-Risk Pregnant Women of Preeclampsia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women with a normal NT scan before 16 weeks of gestation
- Have at least 1 high-risk factor or at least 2 moderate-risk factors for preeclampsia
- Intend to receive prenatal care and deliver at the study hospital
- Provide written informed consent to participate in the study
You will not qualify if you...
- Aspirin started after 16 weeks of pregnancy
- Allergy or intolerance to aspirin
- Taking less than 80% of prescribed aspirin
- Miscarriage or pregnancy termination before randomization
- Dropped out by not returning to hospital for delivery
- Lost to follow-up during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
FANG HE
Guangzhou, Guangdong, China, 510150
Actively Recruiting
Research Team
F
Fang He, M.D
CONTACT
Q
Qingwen Nie, Master
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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