Actively Recruiting
Aspirin-free Strategy With Ticagrelor in Patients With a Myocardial Infarction Treated Medically Alone
Led by Montreal Heart Institute · Updated on 2026-03-10
2570
Participants Needed
1
Research Sites
252 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In patients with a myocardial infarction (MI) treated medically alone, the objective of the PANTHEON trial is to evaluate if ticagrelor monotherapy reduces bleeding events, without an increase in patient-oriented ischemic events, compared with standard dual antiplatelet therapy (DAPT) with aspirin and ticagrelor for 12 months.
CONDITIONS
Official Title
Aspirin-free Strategy With Ticagrelor in Patients With a Myocardial Infarction Treated Medically Alone
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 618 years
- Hospitalized for type 1 myocardial infarction according to the 4th Universal Definition of MI
- Coronary angiogram performed
- Planned for medical management alone, without revascularization
- Willingness to participate and attend study visits
- Expected life expectancy of 12 months or more
You will not qualify if you...
- Hospitalized for type 2-5 myocardial infarction or unstable angina according to the 4th Universal Definition of MI
- Hospitalized for STEMI with an acute thrombotic lesion of a major epicardial vessel
- Elevations in cardiac biomarkers believed not to be of ischemic origin (e.g., myocardial injury, myocarditis, Takotsubo syndrome)
- Confirmed or suspected spontaneous coronary artery dissection
- Need for chronic oral anticoagulant therapy
- Non-coronary indication for dual antiplatelet therapy
- Use of any non-trial antiplatelet drug that must be continued
- Previous hospitalization for MI, PCI, or CABG within 12 months
- Known hypersensitivity, intolerance, or contraindication to aspirin or ticagrelor
- Unsuitability for either randomization treatment based on physician judgment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Montreal Heart Institute
Montreal, Quebec, Canada, H1Y2P3
Actively Recruiting
Research Team
G
Guillaume Marquis-Gravel, MD
CONTACT
R
Roseline Therrien
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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