Actively Recruiting
Aspirin and Preeclampsia
Led by University of Chicago · Updated on 2026-05-04
180
Participants Needed
1
Research Sites
306 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-center, double-blind, randomized, placebo-controlled clinical trial. Peripartum and postpartum Activin A are significantly elevated in women with preeclampsia. Our hypothesis is that elevated Activin A levels reflect a remediable signal and that reducing postpartum Activin A levels with aspirin therapy will improve (GLS) in preeclamptic patients.
CONDITIONS
Official Title
Aspirin and Preeclampsia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant adults between 18 and 45 years of age
- Diagnosed with preeclampsia
- Presenting for delivery with a singleton pregnancy
You will not qualify if you...
- Patients in labor
- History of cardiomyopathy, chronic hypertension, ischemic or valvular heart disease, pulmonary disease, diabetes mellitus, or chronic kidney disease
- Multiple pregnancy (more than one fetus)
- Planning to deliver outside the study site
- Participation in other trials that might affect study medication use
- Allergy to aspirin
- Clear need for aspirin therapy or any contraindication to aspirin
- Conditions that may limit following the study, such as peptic ulcers, gastrointestinal bleeding, or bleeding disorders
- Currently using or planning to take nonsteroidal anti-inflammatory drugs during the study
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Chicago Hospital
Chicago, Illinois, United States, 60637
Actively Recruiting
Research Team
S
Sajid Shahul, MD, PhD
CONTACT
C
Colleen Duncan, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
PREVENTION
Number of Arms
3
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