Actively Recruiting

Phase 4
Age: 40Years - 70Years
All Genders
NCT06676280

ASpirin Use and stAtin Strategy for Primary Prevention in Severe Coronary Calcium Score on Computed Tomography

Led by Jung-min Ahn · Updated on 2026-01-29

5000

Participants Needed

1

Research Sites

544 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The primary objective of the ASA-3C trial is to evaluate the role of aspirin and high-intensity statin therapy, respectively, in individuals with severe coronary calcification (coronary calcium score ≥300) to prevent atherosclerotic cardiovascular disease (ASCVD) events with severe coronary calcification (CAC ≥300).

CONDITIONS

Official Title

ASpirin Use and stAtin Strategy for Primary Prevention in Severe Coronary Calcium Score on Computed Tomography

Who Can Participate

Age: 40Years - 70Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged between 40 and 70 years
  • Have coronary artery calcium score 300 or higher on coronary calcium computed tomography
  • Have at least one cardiovascular disease risk factor: dyslipidemia, diabetes, hypertension, family history of cardiovascular disease, or smoking
  • Agree to follow the study protocol and schedule and provide informed written consent
Not Eligible

You will not qualify if you...

  • Have symptomatic coronary artery disease or heart failure
  • Have documented clinical atherosclerotic cardiovascular disease including previous heart attack, acute coronary syndrome, stable angina, coronary or other arterial revascularization, stroke, transient ischemic attack, significant carotid stenosis, aortic aneurysm, or peripheral artery disease
  • Show evidence of myocardial ischemia on stress tests or invasive coronary angiography with fractional flow reserve less than 0.80
  • Are at high risk of bleeding or have had recent gastrointestinal hemorrhage or peptic ulcer
  • Have active liver disease, severe left ventricular dysfunction, severe valvular heart disease with exertional dyspnea, atrial fibrillation or flutter
  • Have history of allergy or severe reaction to aspirin, statins, or ezetimibe
  • Have recent myositis or myopathy
  • Have abnormal safety findings on physical exam, blood tests, or ECG
  • Have history of alcohol or drug abuse
  • Have medical conditions limiting life expectancy to less than 1 year
  • Are pregnant or breastfeeding
  • Unable to provide informed consent or participate in long-term follow-up

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Asan Medical Center

Seoul, South Korea

Actively Recruiting

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Research Team

J

Jung-min Ahn, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

FACTORIAL

Primary Purpose

PREVENTION

Number of Arms

4

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