Actively Recruiting
ASSESS ALL ALS Study
Led by St. Joseph's Hospital and Medical Center, Phoenix · Updated on 2026-01-12
2000
Participants Needed
32
Research Sites
260 weeks
Total Duration
On this page
Sponsors
S
St. Joseph's Hospital and Medical Center, Phoenix
Lead Sponsor
M
Massachusetts General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The ALL ALS Clinical Research Consortium is establishing research to collect a wide range of samples, clinical information and measurements from Amyotrophic Lateral Sclerosis (ALS) symptomatic, ALS gene carriers and control cohorts. This consortium is being funded by the National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) and managed by two clinical coordinating centers (CCC) at Barrow Neurological Institute and Massachusetts General Hospital. The clinical sites are distributed across the country, and led by a group of collaborative principal investigators. Once data and samples are collected and harmonized, it will be made available to research community for future research into ALS and related neurological diseases. ASSESS protocol is specific for symptomatic ALS and control participants. This protocol includes both on-site and off-site(remote) participants. The participants will be followed for 24 months (2 years), and will include collection of medical history, clinical outcomes, and blood samples once in 4 months. Additionally, the participants will complete patient reported outcomes and speech recordings once a month. Participants who are coming into clinic may also provide optional Cerebrospinal Fluid (CSF) samples.
CONDITIONS
Official Title
ASSESS ALL ALS Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Capable of providing informed consent
- Willing to follow study procedures
- Diagnosis of ALS by a physician (for ALS participants)
- No diagnosis of ALS, Progressive Muscular Atrophy (PMA), or Primary Lateral Sclerosis (PLS) (for control participants)
- No history of familial ALS/Frontotemporal Dementia (FTD) in a close family member unless previously tested negative for known ALS genes (for control participants)
- Access to a smartphone, computer, or tablet with internet access (home or public access)
You will not qualify if you...
- Significant cognitive impairment, clinical dementia, or unstable psychiatric illness that would interfere with study procedures
- Clinically significant unstable medical condition other than ALS making 12 months follow-up unlikely
- Medically unable to undergo lumbar puncture (for those opting for lumbar puncture)
- Allergy to local anesthetics such as Lidocaine (for lumbar puncture)
- Use of anticoagulant or antiplatelet medications that cannot be safely stopped before lumbar puncture
- Blood disorders or dialysis treatment for renal failure (for lumbar puncture)
- Current pregnancy (for lumbar puncture)
- Investigator judgment deeming participant unable to undergo multiple lumbar punctures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 32 locations
1
University of Alabama Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
Barrow Neurological Institute
Phoenix, Arizona, United States, 85013
Actively Recruiting
3
University of California, Irvine
Irvine, California, United States, 92868
Actively Recruiting
4
University of California San Diego
La Jolla, California, United States, 98037
Actively Recruiting
5
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
6
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
7
Hospital For Special Care
New Britain, Connecticut, United States, 06053
Actively Recruiting
8
Georgetown University
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
9
Mayo Clinic
Jacksonville, Florida, United States, 32224
Actively Recruiting
10
Saint Alphonsus Regional Medical Center
Boise, Idaho, United States, 83704
Actively Recruiting
11
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
12
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
13
John Hopkins University
Baltimore, Maryland, United States, 21205
Actively Recruiting
14
Nih/Ninds
Bethseda, Maryland, United States, 20892
Actively Recruiting
15
Massachusetts General Brigham
Boston, Massachusetts, United States, 02145
Actively Recruiting
16
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
17
Henry Ford Health
Detroit, Michigan, United States, 48202
Actively Recruiting
18
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
19
Washington University
St Louis, Missouri, United States, 63110
Actively Recruiting
20
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
21
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
22
Columbia University
New York, New York, United States, 10032
Actively Recruiting
23
Duke University
Durham, North Carolina, United States, 27705
Actively Recruiting
24
Ohio State University
Colombus, Ohio, United States, 43221
Actively Recruiting
25
Providence ALS Center
Portland, Oregon, United States, 97213
Actively Recruiting
26
Penn State Health
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
27
Temple University
Philadelphia, Pennsylvania, United States, 19140
Actively Recruiting
28
Texas Neurology
Dallas, Texas, United States, 75206
Actively Recruiting
29
University of Utah
Salt Lake City, Utah, United States, 84132
Actively Recruiting
30
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
31
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
32
CHALS-CCT, University of Puerto Rico, Medical Sciences Campus
San Juan, Puerto Rico, Puerto Rico, 00935
Actively Recruiting
Research Team
A
ALL ALS Patient Navigator
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here