Actively Recruiting

Phase 1
Phase 2
Age: 55Years - 90Years
All Genders
Healthy Volunteers
NCT05336695

Assess Fibrin in Brains With AD/ADRD

Led by Massachusetts General Hospital · Updated on 2025-10-30

30

Participants Needed

1

Research Sites

234 weeks

Total Duration

On this page

Sponsors

M

Massachusetts General Hospital

Lead Sponsor

N

National Heart, Lung, and Blood Institute (NHLBI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this project is to quantify brain fibrin content using 64Cu-FBP8-PET in the brains of subjects ranging from cognitively normal to clinically diagnosed with ADRD to evaluate potential regional differences.

CONDITIONS

Official Title

Assess Fibrin in Brains With AD/ADRD

Who Can Participate

Age: 55Years - 90Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 55 and 90 years
  • Ability to provide informed consent
  • Healthy volunteers must have no history of Alzheimer's disease or related dementias
  • ADRD subjects must have a clinical diagnosis of Alzheimer's disease, with severity from mild cognitive impairment to moderate dementia (CDR 0.5-2.0), and MMSE score >= 15 and/or MOCA score >= 12
  • BAnD subjects must be referred through the Brain Aging and Dementia research registry
Not Eligible

You will not qualify if you...

  • Contraindications to MRI such as electrical implants (pacemakers, perfusion pumps), ferromagnetic implants (aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel), tattoos near the eye, or metal clips in clothing
  • Preexisting medical conditions increasing risk of seizures, claustrophobia, or cardiac arrest
  • Estimated glomerular filtration rate (eGFR) less than 60 mL/min excluding gadolinium contrast use
  • Radiation exposure exceeding 50 millisievert in the prior 12 months
  • Pregnancy or breastfeeding; pregnancy must be ruled out in premenopausal women of child-bearing age

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Massachusetts General Hospital

Boston, Massachusetts, United States, 02115

Actively Recruiting

Loading map...

Research Team

C

Ciprian Catana, MD, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here