Observing How Persistent H. Pylori Infection Affects Insulin Resistance in Adults With Metabolic Syndrome

What this Trial Is About

Researchers are investigating the link between persistent Helicobacter pylori infection and the severity of insulin resistance in 100 patients diagnosed with metabolic syndrome. This retrospective cohort study aims to clarify how chronic H. pylori-related inflammation may worsen metabolic factors related to insulin resistance, a key component of metabolic syndrome that contributes to type 2 diabetes, liver disease, and cardiovascular problems. Participants are divided into two groups those with metabolic syndrome who have persistent H. pylori infection and those without the infection. The study evaluates metabolic markers, including insulin resistance measured by the HOMA-IR index, along with inflammatory markers like C-reactive protein CRP and various metabolic parameters such as body mass index, waist circumference, fasting glucose, and cholesterol levels. Measurements are taken within two days of study inclusion. During participation, patients undergo fasting blood tests, breath tests, stool antigen tests, and possibly endoscopy with biopsy to confirm infection status and metabolic parameters. Researchers will compare insulin resistance levels and correlations with inflammation and metabolic markers between infected and non-infected groups. The study is observational and does not include treatment interventions, with participation lasting through the data collection period shortly after inclusion.

Assessing the Association Between H. Pylori Persistence and the Severity of Insulin Resistance in Patients With Metabolic Syndrome