What is this study trying to find out about cancer and cannabis use?

This study is examining how cannabis and cannabinoid use may relate to cancer-related symptoms in adults newly diagnosed with certain cancers. Researchers want to understand potential benefits or harms of cannabis use during cancer treatment. The study is sponsored by Wake Forest University Health Sciences and involves patients receiving systemic cancer therapies.

Who may be eligible for this cancer clinical trial?

Adults aged 18 or older with newly diagnosed breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer may qualify. Participants must be planning or recently started systemic chemotherapy or immune checkpoint inhibitor therapy and able to complete surveys online in English or Spanish. Please review eligibility criteria for more details.

Is there any cost to participate in this cancer clinical trial?

Study-related care, including surveys and medical record reviews, is provided at no cost. Personal expenses like travel may vary and are not guaranteed to be covered. Participants can expect to complete monthly surveys over a year at no charge.

Actively Recruiting

Age: 18Years +

All Genders

ID06418204

Complementary Options for Symptom Management In Cancer COSMIC Assessing Benefits and Harms of Cannabis and Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

Led by Wake Forest University Health Sciences · Updated on 2026-03-17

2000

Participants Needed

467

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying adults newly diagnosed with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer who are planning to receive systemic cancer therapies such as chemotherapy and immune checkpoint inhibitors ICIs. The study aims to understand how cannabis and cannabinoid use relates to cancer-related symptoms over one year. This observational research includes patients treated in community oncology clinics and is sponsored by Wake Forest University Health Sciences. Participants complete surveys and allow medical record reviews throughout the study. The study tracks cannabis and cannabinoid use as well as perceived benefits, harms, and adverse effects monthly for 12 months following enrollment. An optional sub-study is available at select sites for patients with non-small cell lung cancer receiving specific chemotherapy with ICIs. During the study, participants fill out monthly surveys about their symptoms and cannabis use. Researchers also review medical records to assess cancer-related symptoms and treatment progress. The main measure is cancer-related symptoms assessed monthly for up to one year. Secondary measures include cannabis use patterns and adverse effects. Participation involves ongoing survey completion and record review, with the total study duration lasting 12 months post-enrollment.

CONDITIONS

Brief Title

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Adults aged 18 years or older with newly diagnosed breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer
Planned treatment with systemic chemotherapy and/or immune checkpoint inhibitor therapy targeting PD-1, PD-L1, or CTLA-4
Able to understand English or Spanish for survey completion
Have a working email address and willing to complete online surveys
Completed Self-Reported Screening Survey and eligible for enrollment
Reside in the United States as reported by the participant
Life expectancy of at least 6 months according to treating provider
Enrollment allowed up to start of Cycle 2 treatment if not engaged before treatment start
Optional sub-study: receiving treatment at select centers, diagnosed with non-small cell lung cancer, and planning specific chemotherapy with ICIs

You will not qualify if you...

Currently enrolled in an interventional supportive treatment trial for cancer symptoms
Known pregnancy
Received systemic therapy for prior cancers
Enrolled in hospice
Optional sub-study exclusion: use of chronic steroids or immunomodulatory agents (except pre-medications), history of HIV, hepatitis B or C

Research Team

Karen Craver

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here