The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation.
Aikaterini Gatsiou, Simon Tual-Chalot, Matteo Napoli...
https://pubmed.ncbi.nlm.nih.gov/37100060Actively Recruiting
Age: 13Years +
All Genders
ID01099982
Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease, Effects of Mechanical Unloading on Myocardial Function and Structure in Humans
Led by University of Utah · Updated on 2025-07-15
300
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Utah
Lead Sponsor
I
Intermountain Health Care, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating changes in heart tissue and blood in patients with advanced heart disease, focusing on those with end-stage heart failure undergoing left ventricular assist device (LVAD) implantation or heart transplantation. The study aims to collect tissue and serum samples to better understand the basic science of heart disease. Samples from healthy donor hearts not used for transplantation will serve as comparison controls. This observational registry project does not involve any investigational drugs or procedures and focuses on gathering functional, structural, and molecular data related to heart failure. Participants in the advanced heart failure group will have tissue samples collected during their LVAD implantation surgery from the portion of the left ventricular apex removed as part of the procedure. Blood samples will be drawn at specific times during the study, either during scheduled procedures or alongside other lab work. Control samples will be obtained from patients undergoing other cardiac surgeries where tissue is routinely discarded. No additional tissue beyond standard surgical removal will be collected. During the study, participants will provide consent and have blood samples taken at defined time points. Researchers will monitor changes in myocardial function from baseline to three months after procedures. The project stores and organizes collected data and tissue samples for future research but does not affect current treatment plans. The study involves ongoing monitoring and data collection, with overall participation duration varying based on individual procedures and follow-up schedules.
CONDITIONS
Brief Title
Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease
Who Can Participate
Age: 13Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adults over 18 years diagnosed with heart failure undergoing LVAD implantation or heart transplantation
- Children aged 13 to 18 years with heart failure and body size suitable for LVAD placement
You will not qualify if you...
- Neither the patient nor their representative understands spoken English
- Neither the patient nor their representative is willing to provide written consent for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - Day of surgery
Blood and tissue samples are collected during cardiac surgery procedures as part of routine care.
1 visit (in-person)
Long-term Monitoring
Duration - 3 months
Participants are observed for changes in myocardial function over time after surgery.
1 follow-up visit
Trial Site Locations
Total: 3 locations
1
Intermountain Medical Center
Murray, Utah, United States, 84157
Actively Recruiting
2
University of Utah Health Sciences Center
Salt Lake City, Utah, United States, 84132
Actively Recruiting
3
VA Salt Lake City Health Care System
Salt Lake City, Utah, United States, 84148
Actively Recruiting
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Research Team
J
John Kirk
S
Stavros Drakos, M.D., Ph.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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