By Assessing the Continuous Respiratory Physiological Changes Through Prone Position, Determine the Optimal Duration for Prone Position

What this Trial Is About

This research focuses on patients with acute respiratory distress syndrome ARDS to understand how the prone position affects lung ventilation and inflammation. The study aims to determine the best duration for prone positioning therapy by observing changes in regional lung ventilation and inflammation markers using electrical impedance tomography EIT. Researchers hope to clarify how prone positioning improves ventilation distribution by inflating collapsed alveoli and reducing overinflation. Participants will be observed while using the prone position therapy, with EIT employed to monitor continuous lung physiological changes. The study collects clinical, laboratory, imaging, and respiratory data before and after prone positioning over several days. Researchers will analyze biomarker changes and measure the response during up to five days of prone positioning. Participants will undergo serial arterial blood gas tests and other assessments as part of regular care. The primary measure is the response to prone positioning during treatment, while a secondary outcome is mortality at 28 days. The study involves continuous data collection during the prone position period, aiming to improve understanding of therapy duration and its effects on lung function and inflammation in ARDS patients.

By Assessing the Continuous Respiratory Physiological Changes Through Prone Position, Determine the Optimal Duration for Prone Position