Actively Recruiting
By Assessing the Continuous Respiratory Physiological Changes Through Prone Position, Determine the Optimal Duration for Prone Position
Led by National Taiwan University Hospital · Updated on 2025-02-19
100
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on patients with acute respiratory distress syndrome (ARDS) to understand how the prone position affects lung ventilation and inflammation. The study aims to determine the best duration for prone positioning therapy by observing changes in regional lung ventilation and inflammation markers using electrical impedance tomography (EIT). Researchers hope to clarify how prone positioning improves ventilation distribution by inflating collapsed alveoli and reducing overinflation. Participants will be observed while using the prone position therapy, with EIT employed to monitor continuous lung physiological changes. The study collects clinical, laboratory, imaging, and respiratory data before and after prone positioning over several days. Researchers will analyze biomarker changes and measure the response during up to five days of prone positioning. Participants will undergo serial arterial blood gas tests and other assessments as part of regular care. The primary measure is the response to prone positioning during treatment, while a secondary outcome is mortality at 28 days. The study involves continuous data collection during the prone position period, aiming to improve understanding of therapy duration and its effects on lung function and inflammation in ARDS patients.
CONDITIONS
Brief Title
By Assessing the Continuous Respiratory Physiological Changes Through Prone Position, Determine the Optimal Duration for Prone Position
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of acute respiratory distress syndrome
- Age over 18 years
- Serial arterial blood gas data showing PaO2/FiO2 ratio less than 150
- Mechanical ventilator settings with FiO2 greater than 0.6 and PEEP above 5 cmH2O
You will not qualify if you...
- Presence of implantable electronic devices such as pacemakers
- Body mass index greater than 30
- Recent major thoracic or abdominal surgery
- Unstable spine or pelvis conditions
- Pregnant women in second or third trimester
- Head trauma or elevated intracranial or intraocular pressure
- Hemodynamically unstable patients not suitable for prone ventilation
- Active seizure disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 5 days
Participants undergo Electrical Impedance Tomography to monitor continuous respiratory physiological changes during prone position therapy.
Continuous monitoring during prone position
Duration - 28 days
Participants are observed for outcomes including 28-day mortality following prone position therapy.
Follow-up assessments up to 28 days
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
Research Team
T
Ting-Yu Liao, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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