Convenience and Outcomes of Natural Proliferative Phase Frozen Embryo Transfer Compared to Natural Cycle Frozen Embryo Transfer in Women Undergoing IVF

What this Trial Is About

Researchers are evaluating the convenience of the natural proliferative phase frozen embryo transfer NPP-FET compared to the natural cycle frozen embryo transfer NC-FET in women undergoing assisted reproductive techniques. The study focuses on ovulatory patients and aims to analyze the number of appointments needed before cycle scheduling. It also compares reproductive outcomes between the two protocols and investigates if patients undergoing NPP-FET experience ovulation. This observational study addresses concerns related to pregnancy risks and cycle scheduling in frozen embryo transfer. The NPP-FET group will receive vaginal micronized progesterone at 400 mg every 12 hours once the endometrial thickness is at least 7 mm and the dominant follicle is at least 13 mm, with specific hormone levels confirmed. Embryo transfer occurs on the fifth day of progesterone supplementation, and progesterone continues until the 11th week of pregnancy. The control group includes a retrospective cohort of patients who underwent the NC-FET protocol, with embryo transfer timing based on natural ovulation markers and progesterone use after ovulation or hCG trigger. Participants will undergo vaginal ultrasound monitoring between cycle days 8 to 12 to measure follicle and endometrial thickness. Hormone levels such as estradiol, progesterone, and luteinizing hormone are measured to guide treatment. Researchers will track the number of appointments before scheduling, cycle duration until embryo transfer, hormone levels at transfer, pregnancy rates, miscarriage rates, ongoing pregnancies, and live births. Progesterone use and pregnancy monitoring continue for several weeks post-transfer, with total follow-up lasting up to 40 weeks after embryo transfer.

Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer