Study of Phospholipase C Zeta Levels and Their Relationship to Semen Quality in Men Undergoing IVF Treatment

What this Trial Is About

This research investigates the link between phospholipase C zeta PLC levels in sperm and semen quality in men undergoing IVF treatment. Male infertility is a leading cause of infertility worldwide, with genetic factors playing a significant role. The study focuses on how abnormalities in PLC, a sperm-specific protein that triggers calcium oscillations crucial for egg activation and embryo development, relate to male subfertility and fertility treatment outcomes. Participants in this observational study are male partners of couples seeking IVF treatment who have experienced infertility for at least one year. Semen samples are collected and analyzed for PLC levels and standard semen parameters. The study does not involve interventions but follows routine clinical fertility treatment protocols, including embryo culture and genetic testing when applicable. Excess sperm leftover after clinical procedures is used for research analysis. Participants will be monitored from enrollment through treatment outcomes, including biochemical and clinical pregnancy results, and live birth or miscarriage when applicable. Researchers will measure PLC levels at sperm submission and correlate these with semen quality and fertility treatment success. The study aims to improve understanding of male fertility factors and potential diagnostic or therapeutic applications of PLC. Participation duration aligns with the IVF treatment and pregnancy outcome timelines.

Assessing the Correlation Between Phospholipase C Zeta Measurements and Semen Parameters