Actively Recruiting
Assessing CSF Flow Dynamics in Pediatric Hemorrhagic Hydrocephalus
Led by Eva Sevick · Updated on 2025-05-29
20
Participants Needed
1
Research Sites
207 weeks
Total Duration
On this page
Sponsors
E
Eva Sevick
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the safety and efficacy of ventricular microdosing of indocyanine green (ICG) in order to assess cerebrospinal fluid (CSF) ventricular dynamics and extracranial CSF outflow using fluorescent Cap-based Transcranial Optical Tomography (fCTOT) and Near-InfraRed Fluorescent (NIRF) imaging and to evaluate inflammation markers of the CSF and to correlate with CSF ventricular dynamics, extracranial outflow into the lymphatics, ventriculomegaly, and patient's clinical outcome in order to understand how inflammation may impact that status of extracranial outflow.
CONDITIONS
Official Title
Assessing CSF Flow Dynamics in Pediatric Hemorrhagic Hydrocephalus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children born premature currently in the NICU with a diagnosis of PHH who have undergone ventricular reservoir placement.
- For the first four study subjects, the child will attempt to undergo CT cisternography when clinically stable 3-4 weeks after reservoir placement.
You will not qualify if you...
- Parents who do not consent for procedure on their child.
- Children deemed clinically unstable or unsuitable for imaging by clinical staff, including inability to be repositioned without compromising care.
- Children known or suspected to have allergy to iodine or ICG.
- Children without a subcutaneous reservoir for CSF diversion from the lateral ventricle.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
M
Manish Shah, MD
CONTACT
F
Fred C Velasquez
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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