Actively Recruiting
Assessing the Dose-response of Muscle Protein Synthesis to "Super-whey" at Rest and in Response to Acute Exercise in Older Adults
Led by University of Nottingham · Updated on 2026-05-01
30
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Sarcopenia is the loss of skeletal muscle mass and function often seen in older adults, which can impact physical independence and metabolic health. Researchers are studying how different doses of a new leucine-enriched whey protein supplement, called "super-whey," affect muscle building in older adults. This study aims to find the best dose to stimulate muscle protein synthesis, especially since muscle loss is linked to reduced response to protein and exercise in aging. Participants will receive three different low doses of the super-whey protein supplement: 5 grams, 10 grams, and 20 grams. These doses will be given as single bolus servings in a randomized crossover manner, meaning each participant will try all doses in a random order. The doses are considered safe and similar to normal protein intake recommendations. The study will measure muscle protein synthesis both at rest and after acute exercise in older adults. During the study, participants will be monitored for muscle protein fractional synthetic rates at 3 and 6 hours after supplement intake. Blood samples will be taken over 7.5 hours to measure amino acid levels. Participants must be physically able to perform resistance exercise and will be assessed under close supervision by the research team. The study will help understand how different protein doses affect muscle building in older adults and will last until October 2026.
CONDITIONS
Brief Title
Assessing the Dose-response of Muscle Protein Synthesis to "Super-whey" in Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant is 65 years or older and up to 85 years old
- Male gender
- Willing and able to give informed consent
- Physically able to perform resistance exercise
You will not qualify if you...
- Body mass index (BMI) less than 18 or greater than 35 kg/m2
- Active cardiovascular, cerebrovascular, or respiratory disease such as uncontrolled hypertension, angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD, pulmonary hypertension, or recent stroke within 6 months
- Any metabolic disease
- Clotting dysfunction
- History of or current neurological or musculoskeletal conditions (e.g., epilepsy)
- Lactose intolerance
- Participation in a research study with invasive procedures or receiving an inconvenience allowance within the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single-day dosing visits per protein dose
Participants receive 3 different doses of super-whey protein supplements in a randomized crossover fashion, with each dose given as a single bolus. Participants also perform resistance exercise during the study.
3 visits (in-person), one for each protein dose
Trial Site Locations
Total: 1 location
1
Centre of Ageing, Metabolism and Physiology
Derby, United Kingdom, DE22 3DT
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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