Actively Recruiting
Assessing the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor Profile
Led by Midwest Center for Metabolic and Cardiovascular Research · Updated on 2026-04-17
54
Participants Needed
1
Research Sites
20 weeks
Total Duration
On this page
Sponsors
M
Midwest Center for Metabolic and Cardiovascular Research
Lead Sponsor
A
ACH Food Companies, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to assess the effects of corn and avocado oils as part of controlled feeding diets on the cardiometabolic risk factor profile in men and women with mild-to-moderately elevated levels of non-high-density lipoprotein cholesterol (non-HDL-C). Participants will be asked to consume the controlled feeding diet for two separate 21 day conditions, and will consume their regular diet for a 21 day washout period between the two conditions. Additionally, participants will be asked to come into the clinic on 7 different occasions, including one screening visit (visit 1, -7 days), one baseline visit (visit 2, day 0), two visits during each 21-d diet condition (visits 3 \& 6, day 19 and visits 4 \& 7, day 21), and a visit at the conclusion of the washout phase/start of the second diet condition (visit 5, day 0).
CONDITIONS
Official Title
Assessing the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor Profile
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 to 74 years
- Body mass index between 18.5 and less than 35.0 kg/m2
- Fasting non-high-density lipoprotein cholesterol level between 125 mg/dL and less than 225 mg/dL
- Fasting triglyceride level less than 500 mg/dL
- Vein access scale score of 7 to 10
- Generally good health based on medical history and screening
- Daily energy needs of at least 1800 kcal adjusted for physical activity
- Willing to consume only study foods and attend clinic visits each weekday morning during diet periods
- If a smoker, no plans to change smoking habits during the study
- Willing and able to complete study procedures and maintain usual physical activity, avoiding vigorous activity for 24 hours before blood draws
- Signed informed consent and authorization for release of health information
You will not qualify if you...
- Allergy or sensitivity to study products or ingredients
- Abnormal lab test results of clinical significance without acceptable retest
- Fasting blood glucose 126 mg/dL or higher or known diabetes
- Uncontrolled hypertension (systolic ≥160 mm Hg or diastolic ≥100 mm Hg)
- Atherosclerotic cardiovascular disease or related clinical signs
- Significant gastrointestinal, endocrine, renal, hepatic, hematologic, immunologic, dermatologic, pulmonary, pancreatic, neurologic, psychiatric, inflammatory, or biliary disorders
- Cancer within past 2 years except non-melanoma skin cancer
- Recent unstable use of antihypertensive, beta-blockers, high-dose diuretics, thyroid hormones, statins, or lipid-altering medications
- Use of dietary supplements affecting lipid or carbohydrate metabolism within specified periods
- Use of systemic corticosteroids within 4 weeks
- Use of weight-loss drugs or programs recently
- Weight change over 4.5 kg in past 3 months
- Extreme dietary habits or diagnosed eating disorders
- Active infection or recent antibiotic use around blood draw times
- Pregnancy, lactation, or unwillingness to use approved contraception
- Positive urine drug screen
- Recent alcohol or substance abuse
- Exposure to non-registered drugs within 30 days
- Any condition interfering with consent, compliance, or study interpretation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Biofortis Clinical Research
Addison, Illinois, United States, 60101
Actively Recruiting
Research Team
C
Caryn Adams, MPH
CONTACT
S
Sara Campbell, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here