Randomized Crossover Study Comparing Effects of Corn Oil and Avocado Oil on Heart and Metabolic Health in Adults

What this Trial Is About

Researchers are evaluating the effects of corn oil and avocado oil on heart and metabolic health in adults with mildly to moderately high levels of non-HDL cholesterol. The study focuses on how these oils, included in controlled diets, influence factors related to heart disease risk. This is a randomized, double-blind, controlled feeding crossover trial involving men and women aged 18 to 74 with specific cholesterol levels. Participants will consume controlled diets containing either corn oil or avocado oil for two separate 21-day periods, separated by a 21-day washout phase where they eat their regular diet. Each oil is provided in three daily servings incorporated into yogurt, dinner rolls, and muffins, delivering 4 tablespoons per day. The study includes a screening visit, baseline visit, multiple visits during each diet phase, and a visit at the end of the washout period before the second diet begins. Throughout the study, participants will visit the clinic seven times for assessments including blood draws to measure cholesterol types, triglycerides, insulin resistance, and other metabolic markers. Researchers will monitor adherence to the diets, physical activity, and health status. The primary outcome is the change in non-HDL cholesterol from baseline to the end of each diet condition, with additional measures of other cholesterol types and insulin sensitivity. The total duration of participation covers about 10 weeks including all visits and diet phases.

Assessing the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor Profile