Assessing Fluid-responsiveness Using Non-invasive Hybrid Diffuse Optics on Peripheral Muscle

What this Trial Is About

This observational study focuses on critically ill patients in intensive care who have invasive blood pressure monitoring through an arterial line. It aims to evaluate the relationship between cardiac output and microvascular blood flow in peripheral muscles during a Passive Leg Raising (PLR) maneuver. Researchers will assess how microvascular measurements correlate with cardiac output changes and their ability to predict positive cardiac output responses. Participants will undergo a PLR maneuver where their lower limbs are elevated to a 45° angle while the upper body moves from a semi-recumbent to supine position for three minutes before returning to the initial position. During this procedure, microvascular blood flow and tissue oxygen saturation will be measured on the brachioradialis muscle using the hybrid diffuse optics spectroscopy (hDOS) platform. Cardiac output will be monitored invasively through the arterial line using pulse waveform analysis. Throughout the study, researchers will collect data on cardiac output response during the PLR procedure and monitor microvascular parameters over time. This includes measuring blood flow index and tissue oxygen saturation. The study will assess these variables' potential to predict cardiac output increases greater than 10%. The total duration of participant involvement and follow-up details are not specified.

Assessing Fluid-responsiveness Using Non-invasive Hybrid Diffuse Optics on Peripheral Muscle