A framework for the analysis of phantom data in multicenter diffusion tensor imaging studies.
Lindsay Walker, Michael Curry, Amritha Nayak...
https://pubmed.ncbi.nlm.nih.gov/22461391Actively Recruiting
Age: 18Years - 100Years
All Genders
Healthy Volunteers
ID05604534
Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2026-06-03
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
N
National Institute of Neurological Disorders and Stroke (NINDS)
Lead Sponsor
N
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting an observational study to improve the use of magnetic resonance imaging (MRI) by collecting data from healthy adults. The goal is to develop and optimize new quantitative MRI techniques as potential biomarkers to better understand the anatomical and physiological state of human tissues. This study focuses on measuring the accuracy and consistency of these MRI metrics across different scanners and over time. Participants aged 18 years and older in good general health will have at least one MRI scan targeting areas such as the brain, liver, prostate, breast, or other body parts. The scans involve lying inside a tube-shaped MRI machine, with special pads and ear protection provided to ensure comfort and minimize noise. Some participants may be asked to perform tasks on a computer during the scan. They may have up to five scans over three months, and some might have as many as 30 scans per year, participating for up to two years. During the study, participants will undergo physical exams focused on their nervous system and complete questionnaires. The study team will monitor the reproducibility of MRI metrics and assess how experimental design and biological differences affect measurement variability. Safety is considered, and participants can communicate with staff or stop the scan at any time. The total participation duration can be up to two years, with multiple visits and assessments throughout.
CONDITIONS
Brief Title
Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects
Who Can Participate
Age: 18Years - 100Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Willingness to follow all study procedures and be available for the study duration
- Male or female aged 18 years or older
- In good general health based on medical history
- Able to understand and willing to sign informed consent
- Must have had a neurological physical exam within the past two years or as required by policy
You will not qualify if you...
- Have metal implants or objects incompatible with MRI (e.g., pacemakers, medication pumps, aneurysm clips, metallic prostheses, certain orthopedic implants, shrapnel, or metal fragments in the eye)
- Claustrophobia preventing comfortable lying in the scanner for up to 2 hours
- Unable to lie still comfortably for the duration of the scan
- Hearing problems preventing tolerance of scanner noise
- Tattoos or permanent eyeliner considered case-by-case due to heating risk
- Medical conditions needing physiological monitoring during scan (e.g., pulmonary or airway disease, heart failure, coronary artery disease)
- History of any medical condition posing emergency risk during MRI
- For >7T MRI, having ferromagnetic dental crown or bridge
- Non-English speakers
- Pregnant women at enrollment or during participation (enrollment postponed or discontinued if pregnancy detected)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Variable depending on individual participant schedule
Participants undergo quantitative MRI scans to obtain imaging metrics and evaluate reproducibility and variability of these measurements.
1 to multiple MRI scan visits depending on protocol requirements
Long-term Monitoring
Duration - Up to several months or years depending on the study schedule
Participants may be observed over time to assess the stability and reproducibility of MRI metrics across different sessions and scanners.
Follow-up MRI visits as scheduled
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
W
Whitney M Spencer
C
Carlo M Pierpaoli, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
Analysis of the contribution of experimental bias, experimental noise, and inter-subject biological variability on the assessment of developmental trajectories in diffusion MRI studies of the brain.
Neda Sadeghi, Amritha Nayak, Lindsay Walker...
https://pubmed.ncbi.nlm.nih.gov/25583609Quantitative brain MRI.
Carlo Pierpaoli
https://pubmed.ncbi.nlm.nih.gov/21613871