Actively Recruiting
Assessing Optimal XRB Initiation Points in Jail
Led by NYU Langone Health · Updated on 2025-09-10
200
Participants Needed
4
Research Sites
91 weeks
Total Duration
On this page
Sponsors
N
NYU Langone Health
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescriptions who enter Middlesex County House of Corrections (MCHOC) as pre-trial detainees will be randomized at admission on a 1:1 basis to be inducted onto extended-release buprenorphine (XRB) at the time of admission (experimental condition) or remain in SLB (E-TAU; all participants will also receive naloxone). The two approaches will be compared with regard to (1) the percentage of participants released from jail with at least 7 days of buprenorphine in their system, (2) percentage of participants continuing MOUD treatment in the community, and (3) infractions related to buprenorphine diversion.
CONDITIONS
Official Title
Assessing Optimal XRB Initiation Points in Jail
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Incarcerated men able to provide written informed consent in English
- Unsentenced (pre-trial detainees)
- Entering the facility with a prescription for sublingual buprenorphine and receiving it for at least the previous 3 days
- Minimum anticipated jail stay of 4 days
- Willing to accept randomization to either continue sublingual buprenorphine or transition to extended-release buprenorphine injection
You will not qualify if you...
- Sentenced inmates
- Allergy, hypersensitivity, or medical contraindication to either medication
- Chronic pain requiring opioid pain management or other contraindicated medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Tufts University Health Sciences
Boston, Massachusetts, United States, 02111
Actively Recruiting
2
Baystate Health
Springfield, Massachusetts, United States, 01199
Actively Recruiting
3
Middlesex County House of Corrections
New Brunswick, New Jersey, United States, 08902
Actively Recruiting
4
NYU Langone Health - 180 Madison Ave
New York, New York, United States, 10016
Actively Recruiting
Research Team
D
David Farabee
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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