Studying How Diastolic Dysfunction Affects Symptoms in Men with Primary Mitral Regurgitation

What this Trial Is About

This research aims to study patients with primary mitral regurgitation MR to understand how diastolic dysfunction, or decreased left ventricular compliance, relates to symptom burden and exercise capacity. Current guidelines recommend surgery based on MR severity and symptoms, but symptoms do not always correlate with severity. This study explores this disconnect, especially noting differences in females and older patients with certain heart characteristics. Participants with MR preparing for mitral valve surgery or percutaneous intervention will undergo several tests. These include cardiovascular magnetic resonance imaging CMR to measure heart size, function, and scarring cardiopulmonary exercise testing CPET to assess exercise capacity and the Kansas City Cardiomyopathy Questionnaire KCCQ to evaluate quality of life and symptom burden. During left heart catheterization LHC, a specialized catheter will measure pressure and volume changes to assess left ventricular stiffness and diastolic dysfunction. Participants will be observed from enrollment through testing over eight weeks. Researchers will collect data on symptoms, exercise capacity, MR severity, and diastolic function. The study involves detailed heart imaging, exercise testing, questionnaires, and invasive pressure-volume measurements during LHC. These assessments will help clarify the relationship between symptoms, heart function, and MR severity, improving understanding of the condition.

Assessing the Relationship Between Symptoms and Mitral Regurgitnant. Severity