Actively Recruiting
Assessing the Relationship Between Symptoms and Mitral Regurgitnant. Severity
Led by Atlantic Health System · Updated on 2024-12-17
40
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The current American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend surgery in patient with mitral regurgitation (MR) based on 1) the severity of MR and 2) the presence or absence of symptoms. Studies have shown that Cardiovascular Magnetic Resonance (CMR) is an accurate method to quantify the severity of MR. However, studies have also shown that symptoms are not necessarily related to the presence of symptoms. Thus, there appears to be a disconnect between the severity of MR and symptoms. Recent analysis of our data has shown that females and older patients with smaller ventricles, lower stroke volumes, and lower regurgitant volume relative to regurgitant fraction tend to be symptomatic. These findings suggest that decreased left ventricular compliance, i.e. diastolic dysfunction, may play an important role as an etiology of symptoms in patients with mitral regurgitation. The aim of this study is to study the presence of diastolic dysfunction in patients with MR and its association with symptom burden and exercise capacity.
CONDITIONS
Official Title
Assessing the Relationship Between Symptoms and Mitral Regurgitnant. Severity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Able to give informed consent
- Primary (degenerative) mitral regurgitation
- Left ventricular ejection fraction (LVEF) 50% or higher
- Undergoing cardiac catheterization
- Able to exercise on a treadmill
You will not qualify if you...
- Unable to give informed consent
- Secondary (functional) mitral regurgitation
- Left ventricular ejection fraction (LVEF) less than 50%
- Known coronary artery stenosis 70% or greater or past revascularization
- More than mild aortic stenosis, mitral stenosis, aortic regurgitation, tricuspid regurgitation, or pulmonic regurgitation
- Hypertrophic cardiomyopathy
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Morristown Medical Center
Morristown, New Jersey, United States, 07960
Actively Recruiting
Research Team
M
Medical Director, Cardiovascular Imaging, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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