Actively Recruiting
Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire
Led by University of British Columbia · Updated on 2025-09-26
30
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
Sponsors
U
University of British Columbia
Lead Sponsor
V
Vancouver Coastal Health Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to find out if self-collected vaginal swabs can be used to detect early signs of uterine cancer or related conditions in people with Lynch syndrome (LS) who still have their uterus. The study also tests if people with LS are willing and able to collect these samples themselves and whether they find the process acceptable. The main questions this study asks are: * Will people with LS take part in self-collection of vaginal samples, and do they find it acceptable? * Can vaginal DNA mutations predict cancer risk or match results from other genetic or biopsy testing? * Can a cancer risk model used in the general population also help identify risk in people with LS? Participants will: * Answer a health questionnaire about lifestyle and symptoms * Collect their own vaginal swabs and measure their vaginal pH at home using a self-collection kit * Complete short surveys around the time of self-collection and at the end of the study
CONDITIONS
Official Title
Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Lynch syndrome confirmed by genetic testing
- Have an intact uterus
- Age 30 years or older
You will not qualify if you...
- History of endometrial cancer or endometrial hyperplasia
- History of pelvic radiation or endometrial ablation
- Pregnant at the time of study enrolment or during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
VGH Research Pavilion
Vancouver, British Columbia, Canada, V5Z 1M9
Actively Recruiting
Research Team
A
Aline Talhouk, PhD
CONTACT
R
Research Assistant
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SCREENING
Number of Arms
1
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