Actively Recruiting
The Effects of Hass Avocados on Glycemic Control in Persons With Type 2 Diabetes: A Randomized Controlled Crossover Trial
Led by Pennington Biomedical Research Center · Updated on 2025-07-31
48
Participants Needed
1
Research Sites
28 weeks
Total Duration
On this page
Sponsors
P
Pennington Biomedical Research Center
Lead Sponsor
P
Prachi Singh
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to evaluate the effects of Hass Avocados on blood sugar control in adults with Type 2 diabetes. The study investigates whether eating Hass Avocados daily can reduce fasting blood sugar levels compared to consuming an equal calorie amount of other fruits. The trial is randomized and double-blind to carefully assess these effects under controlled conditions. Participants will be randomly assigned to one of two groups: one group will consume one Hass Avocado daily (about 240 calories per day), and the other group will receive other fruits matched for energy and form. This crossover design allows each participant to try both diets during the study period, helping to compare their impacts on blood sugar. During the study, participants will undergo blood tests at the start and after 5 weeks to measure fasting blood glucose, insulin, fructosamine, and glycated albumin levels. Researchers will monitor adherence to the diet and safety throughout the trial. The total participation spans at least 5 weeks per diet phase, with close monitoring of metabolic markers to understand how avocado consumption influences glycemic control.
CONDITIONS
Brief Title
Assessing the Value of Avocados on Glycemic Control in Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant reported diagnosis of Type 2 diabetes
- HbA1c between 5.7% and 11% inclusive, or fasting blood glucose of 100 mg/dL or higher
- Body mass index (BMI) between 27 and 50 kg/m2 inclusive
- Age between 18 and 65 years inclusive
- On a stable medication regimen (including diabetes medications) for at least 3 months
- Willing to follow all study protocol requirements including blood draws
- Under the care of a physician managing diabetes
- Willing to allow release of trial information to treating physician
You will not qualify if you...
- Not willing or unable to consume study foods including avocados
- Participation in a weight control program or weight loss of 5 kg or more in past 3 months
- Use of prescription or over-the-counter weight loss medications within last 4 weeks
- History of weight loss surgery in last 5 years
- Major surgery within 3 months before enrollment
- Type 1 diabetes, insulin-dependent Type 2 diabetes, or use of thiazolidinediones
- Renal insufficiency with potassium over 5.5 mmol/L or creatinine over 2.5 mg/dL
- Bilirubin over 3 mg/dL or albumin less than 3 g/dL
- ALT greater than three times upper limit of normal
- More than one severe hypoglycemic event in past 12 months without physician clearance
- Use of high-dose diuretics (furosemide 40mg or higher)
- Unstable heart disease or implanted cardiac defibrillator
- Blood pressure 180/100 mm Hg or higher (retest allowed within one week)
- Untreated or recently changed thyroid disease treatment
- Uncontrolled gastrointestinal disorders
- Current or recent cancer treatment within 3 years (except certain skin cancers)
- Dementia, psychiatric illness, or substance abuse interfering with adherence
- Pregnancy, lactation, trying to become pregnant, or unwilling to use effective birth control
- Consuming more than 14 alcoholic drinks per week and unwilling to stop during participation
- Participation in another clinical trial within 30 days prior to enrollment
- Any other condition making participation inadvisable by the study physician
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 5 weeks per treatment period
Participants consume either 1 Hass avocado daily or other fruits matched in energy and form, in a randomized crossover design.
Visits occur at baseline and at the end of each 5-week period
Trial Site Locations
Total: 1 location
1
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
Research Team
J
John W Apolzan, PhD
R
Rob Leonard
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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