Actively Recruiting
Assessment of Airway Opening Pressure in Invasively Ventilated Children
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-02-13
50
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
U
URC-CIC Paris Descartes Necker Cochin
Collaborating Sponsor
AI-Summary
What this Trial Is About
Acute respiratory distress syndrome (ARDS) in children is associated with significant morbidity and mortality. Current studies seek to individualize the management of children by defining several phenotypes, based until now mainly on clinical presentation. A better understanding of the respiratory mechanics of each patient could allow the individualization of other phenotypes and adapt their management with individualized ventilation. The method for detecting airway opening pressure (AOP) in children has not yet been validated and the reference methods in adults are difficult to apply in children due to their physiological particularities. The main objective of the study is to evaluate the feasibility of two methods for measuring airway opening pressure in invasively ventilated pediatric patients.
CONDITIONS
Official Title
Assessment of Airway Opening Pressure in Invasively Ventilated Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Minor patients aged > 1 year hospitalized in the pediatric intensive care unit at Necker-Enfants Malades Hospital and receiving invasive ventilation
- Patients meeting PALICC-2 criteria for acute respiratory distress syndrome
- Holders of parental authority must be informed and consent to their child's participation
- Patients must be passively ventilated without respiratory effort during long-term inflation
You will not qualify if you...
- Respiratory mechanics that prevent interpretation of maneuvers due to very low flow or high resistance
- Patients under 1 year of age or weighing less than 10 kilograms
- Refusal of consent by those with parental authority
- Patients not affiliated with social security
- Patients receiving Medical Aid for Life (AME)
- Contraindications to static respiratory mechanics measurements such as pneumothorax, pleural leak, head trauma, threatening intracranial hypertension
- Unstable patients with oxygen saturation below 88%
- Patients receiving nitric oxide or having circuit leaks greater than 20% displayed on the ventilator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hôpital Necker-Enfants Malades
Paris, France, 75015
Actively Recruiting
Research Team
C
Charlotte COLLIGNON, MD
CONTACT
H
Hélène Morel
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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