Actively Recruiting
Assessment of the Alignment of the Atlas and Surrounding Tissues in Chronic Whiplash Associated Disorder
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2024-05-14
90
Participants Needed
1
Research Sites
48 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on chronic whiplash-associated disorder (WAD), a condition caused by rapid neck movement leading to injury of bones or soft tissues and resulting in symptoms like pain and reduced neck movement. The study aims to evaluate the position and alignment of the Atlas (C1 vertebra) in people with chronic WAD compared to those with tension headaches and healthy individuals. It also explores how these factors relate to pain intensity, neck movement limits, daily activities, overall improvement, and quality of life. Participants include healthy controls, patients with chronic WAD (grades 1 or 2), and individuals with tension headache. The study uses advanced MRI imaging to assess the Atlas and surrounding tissues without any intervention. It will measure the feasibility and repeatability of MRI in healthy controls and compare MRI findings among the three groups. The study also collects neurological exam results and patient-reported outcome questionnaires. Participants will undergo MRI scans and neurological exams at specified intervals up to 18 months, with some measures extending to 24 months. Researchers will evaluate repeatability of MRI measurements, alignment of the Atlas, neurological scores, quality of life, muscle volume, fat accumulation, and blood flow. The study includes healthy volunteers aged 18 to 75 years and monitors participants through questionnaires and imaging to understand the relationship between anatomical changes and symptoms in chronic WAD.
CONDITIONS
Brief Title
Assessment of the Alignment of the Atlas and Surrounding Tissues in Chronic Whiplash Associated Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy individuals
- Ability to follow test instructions
- Aged between 18 and 75 years
- For chronic whiplash group: diagnosis of Whiplash Associated Disorder grade 1 or 2
- For tension headache group: diagnosis of tension headache
You will not qualify if you...
- Inability to provide informed consent
- History of claustrophobia
- Unable to follow test instructions
- Contraindications for MRI such as pacemaker or claustrophobia
- Under investigation for undiagnosed disease at time of study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 24 months
Participants undergo advanced MRI imaging to assess the position and alignment of the Atlas (C1) and surrounding tissues, along with neurological examinations and questionnaires.
Multiple visits for MRI scans and assessments over 24 months
Duration - Up to 18 months
Participants are monitored through follow-up assessments including repeatability measurements, neurological examination scores, and quality of life questionnaires.
Periodic follow-up visits during the monitoring period
Trial Site Locations
Total: 1 location
1
Amsterdam UMC
Amsterdam, Netherlands, 1105 AZ
Actively Recruiting
Research Team
N
Nederveen
A
Afzali-Hashemi
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Frequently Asked Questions
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