Study of Anorectal Function and Symptoms in Adults With Inflammatory Bowel Disease and Healthy Volunteers

What this Trial Is About

Researchers are exploring anorectal function in people with inflammatory bowel disease IBD, focusing on those who have symptoms despite their disease being inactive. The study compares symptomatic IBD patients in remission with healthy volunteers and asymptomatic IBD patients to better understand bowel function issues and related psychological symptoms. It also aims to evaluate two different testing methods for rectal sensitivity and compliance. Participants include healthy volunteers aged 18 to 65, asymptomatic IBD patients in remission, and symptomatic patients with ulcerative colitis or Crohns disease affecting the lower bowel or perianal area. The study involves tests using high-resolution anorectal manometry HRAM and a barostat procedure to measure rectal sensitivity and compliance, alongside questionnaires about gastrointestinal symptoms and psychological health. Biological samples such as blood, stool, and mucosal biopsies are collected for molecular analysis. During the study, participants undergo pressure measurements, sensation tests, and complete multiple validated questionnaires assessing symptoms, anxiety, depression, and personality. Researchers will analyze biological samples and correlate findings with clinical and psychological data. The study measures include rectal compliance and sensitivity, anal pressures, coordination during defecation, symptom severity, psychological factors, and molecular markers. This comprehensive approach helps understand the causes of persistent symptoms in IBD remission and the relationship between different assessment methods.

Assessment of Anorectal Function in Patients With Inflammatory Bowel Disease