Study of Risk Factors for Complications in Adults Without a Spleen in France

What this Trial Is About

This research focuses on patients without a functioning spleen, a condition known as asplenia, which can be congenital or acquired through surgery, radiotherapy, or splenic artery embolization. The study aims to assess the risk factors for complications such as infections, cancer, and blood clots in French patients with asplenia. Researchers want to better understand how the immune system and splenic function change over time in these patients. Participants include adults aged 18 and older who have asplenia due to splenectomy, embolization, or radiotherapy. The study is observational and follows patients prospectively over time to monitor complications. It seeks to implement new diagnostic tools to evaluate residual splenic function and improve patient management. The study distinguishes three groups based on the cause of asplenia to examine differences in infection risks. During the study, participants will be followed longitudinally for at least three years to assess complication risk factors. Researchers will use new and existing tools to monitor splenic function and immune status. The main measurement is the incidence of infectious and non-infectious complications. This long-term follow-up aims to provide detailed data on risks faced by asplenic patients to guide better care.

Assessment of Complication Risk Factors in a French National Cohort of Asplenic Patients