The repetition of behavioral assessments in diagnosis of disorders of consciousness.
Sarah Wannez, Lizette Heine, Marie Thonnard...
https://pubmed.ncbi.nlm.nih.gov/28543735Actively Recruiting
Led by BDH-Klinik Hessisch Oldendorf · Updated on 2026-03-11
110
Participants Needed
1
Research Sites
17 weeks
Total Duration
Researchers are evaluating diagnostic methods to better assess consciousness levels in patients with severe brain injury. This study focuses on improving the accuracy and feasibility of evaluating consciousness disorders, such as coma, Unresponsive Wakefulness Syndrome (UWS), and Minimally Conscious State (MCS). The study compares two behavioral assessment tools: the widely used Coma Recovery Scale-Revised (CRS-R) and a newer, shorter tool called the Simplified Evaluation of CONsciousness Disorders (SECONDs). Participants will undergo structured behavioral assessments using both the SECONDs and CRS-R tools during a neurological rehabilitation phase. The study will analyze the diagnostic consistency and clinical relevance of SECONDs compared to CRS-R, aiming to confirm whether SECONDs offers a reliable and quicker alternative for routine clinical use. The study also includes a follow-up 12 months later to evaluate long-term functional outcomes based on initial SECONDs assessments. During the study, patients will be assessed shortly after admission to rehabilitation (6-8 days) using both tools. Follow-up information will be collected via structured telephone interviews with relatives or legal representatives to monitor patients' functional status one year later. Researchers will measure agreement between SECONDs and CRS-R scores, diagnostic stability, prognostic value for long-term outcomes, and the practical feasibility of SECONDs in clinical settings.
CONDITIONS
Assessment of Consciousness With CRS-R and SECONDs
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 to 8 days after admission to neurological rehabilitation
Participants undergo structured behavioral assessments using the Simplified Evaluation of CONsciousness Disorders (SECONDs) and the Coma Recovery Scale-Revised (CRS-R) to evaluate consciousness levels during neurological rehabilitation.
1 to 2 visits depending on assessments
Duration - 12 months after admission
Participants’ functional outcomes are assessed through structured telephone interviews with relatives or legal representatives to evaluate prognostic validity of the SECONDs classification.
1 follow-up telephone interview
Total: 1 location
1
BDH-Klinik Hessisch Oldendorf
Hessisch Oldendorf, Lower Saxony, Germany, 31840
Actively Recruiting
M
Melanie Boltzmann, PhD
S
Simone B. Jenner
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Sarah Wannez, Lizette Heine, Marie Thonnard...
https://pubmed.ncbi.nlm.nih.gov/28543735Caroline Schnakers, Audrey Vanhaudenhuyse, Joseph Giacino...
https://pubmed.ncbi.nlm.nih.gov/19622138