Actively Recruiting
Assessment of the Functional Outcome and Quality of Life in Sarcoma Patients
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2026-03-16
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Primary bone and soft tissue sarcomas are rare cancers that affect the bones and soft tissues, often in the limbs. These cancers make up only about 1% of all diagnosed malignancies. Advances in chemotherapy and imaging have improved survival rates and allowed earlier diagnosis and more accurate staging. Many patients with sarcomas around the knee joint face difficult decisions about which surgical procedure will best meet their needs for function and appearance. Research has shown differences in quality of life and functional outcomes among patients who undergo different surgeries such as amputation, endoprosthetic reconstruction, or rotationplasty. The study evaluates patients who underwent limb salvage surgery for sarcomas in the lower extremities, including both bone and soft tissue sarcomas. Participants include those who had surgical resection of deep soft tissue sarcomas of the thigh or bone and soft tissue sarcomas of the lower limb. A control group of healthy, age-matched individuals will also be included for comparison. Assessments include 3D-motion analysis and strength testing to evaluate functional outcomes, as well as health-related quality of life questionnaires like the Quality of Life Questionnaire C-30 (QLQ-C30), the Impact on Participation and Autonomy Questionnaire (IPAQ), and the Musculoskeletal Tumor Society Score (MSTS). Participants are involved in comprehensive assessments of their gait, muscle strength, and quality of life at least one year after their surgery. These evaluations will help measure their functional abilities, autonomy, and overall quality of life. The study aims to better understand movement strategies and rehabilitation needs, especially for those recovering from soft tissue sarcoma surgery. The main outcomes will be assessed within one year, and the study includes participants aged 18 to 95 years who have consented to participate.
CONDITIONS
Brief Title
Assessment of the Functional Outcome and Quality of Life in Sarcoma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who underwent limb salvage surgery for bone or soft tissue sarcoma of the lower extremity at UZ Leuven
- Aged between 18 and 95 years
- At least one year has passed since surgery
- Informed consent has been obtained
You will not qualify if you...
- Patients who had major surgery of the lower limbs or have any condition affecting the locomotor system
- Skeletally immature individuals
- Informed consent has not been obtained
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 year
Participants undergo 3D-motion analysis, strength assessment, and complete quality of life questionnaires to evaluate their functional status and well-being after sarcoma surgery.
Assessments conducted periodically within 1 year
Trial Site Locations
Total: 1 location
1
UZ Leuven
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
Research Team
H
Hazem Wafa
M
Moke Lieven
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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