Actively Recruiting
Radiographic and Histomorphometric Assessment of Guided Bone Regeneration Using Xenograft Mixed With Allogenic Bone Graft Versus Xenograft Mixed With Autogenous Bone Graft for Augmentation of Deficient Maxillary Alveolar Ridges
Led by Cairo University · Updated on 2026-04-14
32
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effect of mixing allogenic bone graft with xenograft, compared to mixing autologous bone graft with xenograft, for rebuilding deficient maxillary (upper jaw) ridges. The study focuses on guided bone regeneration in patients who have insufficient bone in the maxillary ridge for dental implant placement. It aims to see if the allogenic-xenograft mixture is as effective as the autologous-xenograft mixture in terms of bone ridge dimensions and quality of new bone formed. The trial compares two groups: one receiving a 1:1 mix of xenograft and allogenic bone graft chips, and the other getting a 1:1 mix of xenograft and autologous bone particles harvested from the mandibular ramus (lower jaw). A full-thickness flap is raised to access the ridge, the bone is prepared by decortication, and the grafts are applied and covered with a collagen membrane secured by tacks. The surgical site is closed with resorbable sutures. Both groups receive preoperative and 6-month postoperative cone beam CT scans to measure bone changes. Follow-up visits occur frequently for the first month and then monthly for three months. Participants undergo clinical and radiographic examinations before surgery to confirm eligibility and oral health. After six months, a second surgery collects bone biopsies for histological analysis and places dental implants. Researchers measure horizontal bone gain, ridge height, new bone formation, and residual graft material at six months. Patients receive antibiotics, anti-inflammatory medication, and antiseptic mouth rinse post-surgery, with instructions to avoid trauma to the area. The study lasts at least six months with detailed monitoring of bone regeneration and healing.
CONDITIONS
Brief Title
Assessment Of Guided Bone Regeneration Using Xenograft Mixed With Allogenic Bone Graft Versus Xenograft Mixed With Autogenous Graft For Augmentation Of Maxillary Alveolar Ridges
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 20 to 50 years
- Partially or completely edentulous maxillary ridges
- Insufficient bone width ranging from 2 to 4 mm for implant placement
- Minimum vertical bone height of 10 mm to nasal or sinus floor
- Medically healthy individuals without systemic diseases
- Adequate space for implant prosthetic placement
You will not qualify if you...
- Presence of pathological lesions at the defect site
- Systemic diseases affecting bone metabolism, including uncontrolled diabetes
- Recent or ongoing chemotherapy or radiotherapy
- Medical conditions contraindicating surgery
- Use of medications that may affect healing, such as corticosteroids or bisphosphonates
- Vertical bone deficiency
- Habits like alcoholism or para-functional habits that may affect implant success
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single surgical procedure with postoperative care
Participants undergo guided bone regeneration surgery to augment deficient maxillary alveolar ridges using either a xenograft mixed with allogenic bone graft or a xenograft mixed with autogenous bone graft. Surgery involves flap elevation, decortication, graft placement, and membrane fixation, followed by suturing.
Every other day visits for the first week, weekly visits for the first month, then monthly visits for 3 months
Duration - 6 months post initial surgery
Participants have a second surgery after 6 months for re-entry, core biopsy for histomorphometric analysis, and dental implant placement in the augmented ridge. Postoperative CBCT scans are done to assess bone gain and healing.
1 second stage surgery visit and 1 CBCT scan visit at 6 months
Trial Site Locations
Total: 1 location
1
Faculty of Dentistry Cairo University
Cairo, Egypt
Actively Recruiting
Research Team
M
Mohamed A. Abousetta
M
Mohamed M. Shaker
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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