Comparing Bone Regeneration in Maxillary Ridges Using Xenograft Mixed With Allogenic Versus Autogenous Bone Grafts

What this Trial Is About

Researchers are investigating the effect of mixing allogenic bone graft with xenograft, compared to mixing autologous bone graft with xenograft, for rebuilding deficient maxillary upper jaw ridges. The study focuses on guided bone regeneration in patients who have insufficient bone in the maxillary ridge for dental implant placement. It aims to see if the allogenic-xenograft mixture is as effective as the autologous-xenograft mixture in terms of bone ridge dimensions and quality of new bone formed. The trial compares two groups one receiving a 11 mix of xenograft and allogenic bone graft chips, and the other getting a 11 mix of xenograft and autologous bone particles harvested from the mandibular ramus lower jaw. A full-thickness flap is raised to access the ridge, the bone is prepared by decortication, and the grafts are applied and covered with a collagen membrane secured by tacks. The surgical site is closed with resorbable sutures. Both groups receive preoperative and 6-month postoperative cone beam CT scans to measure bone changes. Follow-up visits occur frequently for the first month and then monthly for three months. Participants undergo clinical and radiographic examinations before surgery to confirm eligibility and oral health. After six months, a second surgery collects bone biopsies for histological analysis and places dental implants. Researchers measure horizontal bone gain, ridge height, new bone formation, and residual graft material at six months. Patients receive antibiotics, anti-inflammatory medication, and antiseptic mouth rinse post-surgery, with instructions to avoid trauma to the area. The study lasts at least six months with detailed monitoring of bone regeneration and healing.

Assessment Of Guided Bone Regeneration Using Xenograft Mixed With Allogenic Bone Graft Versus Xenograft Mixed With Autogenous Graft For Augmentation Of Maxillary Alveolar Ridges