Evaluating L-PRF and Nanohydroxyapatite Materials for Pulpotomy Treatment in Mature Lower First Molars with Irreversible Pulpitis

What this Trial Is About

This research aims to evaluate the clinical and radiographic effects of different materials used in pulpotomy treatment for mature mandibular first molars with irreversible pulpitis. The study compares three groups one using hydroxyapatite, another using L-PRF Leukocyte-Platelet Rich Fibrin, and the third using a combination of nanohydroxyapatite mixed with L-PRF. The goal is to assess how these materials perform in preserving tooth vitality and promoting healing. Participants will receive pulpotomy treatment where the coronal pulp tissue is removed while preserving the root pulp to maintain tooth vitality. Three groups will be treated differently one with hydroxyapatite, another with L-PRF, and the third with the combined nanohydroxyapatite and L-PRF material. The study is randomized and double-blinded, comparing clinical and radiographic outcomes among the groups. During the study, participants will be monitored for postoperative pain at 6, 12, 24, and 72 hours, and again at 7 days after treatment. Long-term evaluation includes checking for dentine bridge formation at 12 months post-treatment. Follow-up visits will assess healing and any clinical or radiographic changes. The total participation period involves regular assessments to measure treatment effects and safety.

Assessment of L-PRF, Nanohydroxyapatite Combined With L-PRF Using Pulpotomy in Mature Mandibular First Molars