Actively Recruiting
Clinical and Radiographic Assessment of L-PRF, Nanohydroxyapatite Combined With L-PRF Scaffold in Vital Pulp Therapy for Mature Mandibular First Molars
Led by Future University in Egypt · Updated on 2024-09-26
45
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the clinical and radiographic effects of different materials used in pulpotomy treatment for mature mandibular first molars with irreversible pulpitis. The study compares three groups: one using hydroxyapatite, another using L-PRF (Leukocyte-Platelet Rich Fibrin), and the third using a combination of nanohydroxyapatite mixed with L-PRF. The goal is to assess how these materials perform in preserving tooth vitality and promoting healing. Participants will receive pulpotomy treatment where the coronal pulp tissue is removed while preserving the root pulp to maintain tooth vitality. Three groups will be treated differently: one with hydroxyapatite, another with L-PRF, and the third with the combined nanohydroxyapatite and L-PRF material. The study is randomized and double-blinded, comparing clinical and radiographic outcomes among the groups. During the study, participants will be monitored for postoperative pain at 6, 12, 24, and 72 hours, and again at 7 days after treatment. Long-term evaluation includes checking for dentine bridge formation at 12 months post-treatment. Follow-up visits will assess healing and any clinical or radiographic changes. The total participation period involves regular assessments to measure treatment effects and safety.
CONDITIONS
Brief Title
Assessment of L-PRF, Nanohydroxyapatite Combined With L-PRF Using Pulpotomy in Mature Mandibular First Molars
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 15 to 30 years
- Patients of any gender
- Patients free from any systemic disease
- Patients who agree to consent and commit to follow-up
- Normal soft tissues around the tooth with no swelling or sinus tract
- Restorable tooth with signs and symptoms of irreversible pulpitis and mature roots
- Tooth shows positive response to cold test
- No internal or external resorption or periapical lesions
You will not qualify if you...
- Pregnant or lactating females
- Patients with mental disturbance
- Patients unable or unwilling to participate in 6-month follow-up
- Tooth with immature roots
- Patients with necrotic pulp
- Tooth with periapical lesions or infections
- Soft tissue with fistula or swelling
- Inability to control bleeding after 10 minutes post-pulpotomy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment visit
Participants undergo pulpotomy using one of three materials: hydroxyapatite, L-PRF, or a combination of L-PRF and nanohydroxyapatite.
1 visit (in-person)
Duration - Up to 12 months post treatment
Participants are assessed for post-operative pain and dentine bridge formation after treatment.
Visits at 6, 12, 24, 72 hours, 7 days, and 12 months after treatment
Trial Site Locations
Total: 1 location
1
future university in Egypt
Cairo, New Cairo, Egypt, 11835
Actively Recruiting
Research Team
N
nada A metwally, master
T
toka A metwally, bachelor's
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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