Actively Recruiting
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
Led by Assiut University · Updated on 2025-01-29
90
Participants Needed
1
Research Sites
48 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to investigate the effect of preoperative administration of intravenous or nebulized tranexamic acid on surgical field, blood loss, anesthetic consumption and hemodynamics of patients undergoing FESS. Primary outcome Modena Bleeding Score (MBS) assessing surgical field Secondary outcome 1. Patient hemodynamics. 2. Anesthetic consumption, Extra doses of fentanyl and propofol and sevoflurane\>2 3. Postoperative complications: including any adverse effects to TXA e.g.nausea, vomiting, any visual disturbances, fits, and any thrombotic manifestation.
CONDITIONS
Official Title
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Either sex
- Age 18-65 years
- ASA I-II patients listed for elective functional endoscopic sinus surgery (FESS) under general anesthesia
- Normal coagulation profile and hematocrit value 30
You will not qualify if you...
- Chronic renal failure
- Liver cirrhosis
- Bleeding disorders
- Current anticoagulant therapy
- Pregnancy or breastfeeding
- Impaired color vision
- Severe vascular ischemia
- History of venous thrombosis or pulmonary embolism
- Long-term treatment with acetylsalicylic acid or NSAIDs not discontinued before surgery
- Hemoglobin concentration <10 mg/dl
- Allergy to tranexamic acid
- Body mass index >35 kg/m2
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Main building, Assiut University Hospitals
Asyut, Egypt
Actively Recruiting
Research Team
A
Asmaa Shabaan Zanaty, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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