Actively Recruiting
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
Led by University of Alabama at Birmingham · Updated on 2026-02-20
120
Participants Needed
1
Research Sites
477 weeks
Total Duration
On this page
Sponsors
U
University of Alabama at Birmingham
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer \[F-18\]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-invasive measure of neuroinflammation. The primary objective of this study is to determine if pain and fatigue patients have higher levels of neuroinflammation than HC individuals as measured with \[F-18\]DPA-714-PET/MRI.
CONDITIONS
Official Title
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 to 65 years of age
- Healthy volunteer or clinical diagnosis of Multiple Sclerosis
- Meets 2016 American College of Rheumatology criteria for fibromyalgia
- Meets 1994 Fukuda criteria for Chronic Fatigue Syndrome
You will not qualify if you...
- Contraindication to MRI
- Pregnancy
- Lactation
- Unable to participate in imaging due to severe medical condition
- Chronic infectious diseases such as HIV or HCV
- Viral or bacterial illness needing medical attention or antibiotics within 1 month
- Diagnosis of cancer including leukemia
- Blood or clotting disorders
- Autoimmune disease diagnosis except for individuals with MS
- Positive urine or serum pregnancy test near time of procedure
- Currently enrolled in a clinical trial with experimental therapies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham Medical Center
Birmingham, Alabama, United States, 35294
Actively Recruiting
Research Team
J
Jared Younger, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here