Actively Recruiting
Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes Mellitus
Led by Azienda Ospedaliero-Universitaria di Parma · Updated on 2025-03-18
70
Participants Needed
1
Research Sites
193 weeks
Total Duration
On this page
Sponsors
A
Azienda Ospedaliero-Universitaria di Parma
Lead Sponsor
U
University of Parma
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goals of this project are to build an experimental tool to dissect out in vivo pancreatic beta cell mass (BCM) and beta cell function (BCF) and to assess for the first time these two determinants of beta cell functional mass (BCFxM) in obesity and in various stages of type 1 and type 2 diabetes mellitus.
CONDITIONS
Official Title
Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes Mellitus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older and 75 years or younger
- Both sexes are eligible
- Participants must be in good health
- Must not meet any exclusion criteria
- Able to understand the study methods, goals, and provide free, written informed consent
You will not qualify if you...
- Hemoglobin less than 12 g/dl
- HbA1c greater than 10%
- Pregnancy or breastfeeding
- Women not in menopause must use effective birth control or agree to pregnancy testing
- History of severe psychiatric disorder or alcohol abuse
- Recent head trauma within 6 months
- Active neurological diseases
- Claustrophobia
- Active malignant cancers
- Severe kidney or liver disease
- Recent major cardiovascular events within 6 months
- Heart failure classified as NYHA class 3 or 4
- Use of drugs affecting beta cell function or insulin sensitivity
- Current or past treatment with GLP1 receptor agonists
- Intolerance to exenatide
- Endocrine diseases affecting beta cell function or insulin sensitivity, except well-controlled hypothyroidism or adrenal insufficiency
- COPD requiring daytime oxygen therapy
- Any current acute illness
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Azienda Ospedaliero Universitaria di Parma
Parma, Pr, Italy, 43126
Actively Recruiting
Research Team
R
Riccardo Bonadonna, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
7
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