Actively Recruiting
Assessment of PET Tracers to Evaluate T Cell Change and Activation in Relation to Immunotherapy Treatment Response in Non-Small Cell Lung Cancer
Led by Amsterdam UMC, location VUmc · Updated on 2025-04-02
34
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
Sponsors
A
Amsterdam UMC, location VUmc
Lead Sponsor
F
Foundation for the National Institutes of Health
Collaborating Sponsor
AI-Summary
What this Trial Is About
The iRelate is a PET imaging trial to compare two upcoming and promising T cell PET tracers. Following chemo-immuno therapy, as part of standard care, NSCLC patients will be recruited to receive two PET scans, shortly before their surgery. Both PET scans will be compared to each other, as well as compared to the pathological analysis of the resected tumor. This study will provide detailed information on the unique as well as additive capacities of imaging biomarkers derived from the immune cell targeting PET tracers.
CONDITIONS
Official Title
Assessment of PET Tracers to Evaluate T Cell Change and Activation in Relation to Immunotherapy Treatment Response in Non-Small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed NSCLC
- Tumor stage T1-4N0-2 with lesion size of 2 cm or larger at restaging FDG PET/CT
- Planned surgery after chemo-immunotherapy following routine guidelines
- Able and willing to give written informed consent
- 18 years of age or older at time of consent
- Measurable disease based on RECIST 1.1 criteria
- ECOG performance status 0-1 and operable based on pulmonary function or exercise tests
You will not qualify if you...
- Patients considered inoperable
- Patients who have had spleen removal (splenectomy)
- Received any vaccination within 14 days before enrollment
- Need systemic corticosteroids over 10 mg prednisone equivalent daily or other immunosuppressive drugs within 14 days before day 0
- Have psychiatric or substance abuse conditions that interfere with trial participation
- Pregnant, breastfeeding, or planning to conceive during the trial period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Amsterdam UMC, location VUmc
Amsterdam, North Holland, Netherlands, 1081 HV
Actively Recruiting
Research Team
M
Maarten Slebe, Msc.
CONTACT
I
Idris Bahce, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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