The inter- and intra-individual variance in descending pain modulation evoked by different conditioning stimuli in healthy men.
Yuka Oono, Hongling Nie, Renata Lima Matos...
https://pubmed.ncbi.nlm.nih.gov/29913755Actively Recruiting
Phase Not Applicable
Age: 0 - 60Years
All Genders
Healthy Volunteers
ID07178288
Assessment of Pressure Pain Threshold and Conditioned Pain Modulation After Effect in Patients With and Without Tennis Elbow
Led by The Hashemite University · Updated on 2025-11-18
38
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how people with and without tennis elbow (lateral elbow tendinopathy) experience pressure pain and how their body's natural pain reduction responds after cold exposure. This study focuses on measuring pressure pain threshold (PPT) and conditioned pain modulation (CPM) to understand pain sensitivity and its changes, which may help improve future assessments and treatments for musculoskeletal pain conditions. The study is a quasi-experimental reliability and time-course investigation conducted at Hashemite University. Participants complete brief questionnaires including demographic information, a tennis-elbow symptom form, and a physical activity form. They undergo a Pressure Pain Threshold (PPT) test using a handheld device that applies increasing pressure to spots near the elbow and wrist. To assess conditioned pain modulation (CPM), one hand is placed in ice water for two minutes while PPT is measured before, during, and after the cold stimulus at set intervals. Testing includes repeated PPT measurements at specific times and a rest period between protocols. Participants attend a single test session for PPT testing, lasting about 30 minutes, and a separate CPM session lasting about 1.5 hours. The study uses standardized procedures, repeated measures, and stored coded data. Researchers measure PPT reliability and the duration of CPM after-effects by tracking how long it takes for pain sensitivity to return to baseline. The study involves healthy adults and patients with confirmed tennis elbow, with safety and data quality emphasized throughout the process.
CONDITIONS
Brief Title
Assessment of Pressure Pain Threshold (PPT) and Conditioned Pain Modulation (CPM) After Effect in Patients With and Without Tennis Elbow (TE)
Who Can Participate
Age: 0 - 60Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Patients with tennis elbow confirmed by the primary investigator
- Unilateral elbow pain lasting more than 6 weeks
- Pain reproduced on at least two specific tests including palpation, isometric testing, middle finger extension, passive wrist stretch, resisted hand gripping, or upper limb neurodynamic test
- Adults without pain for at least 3 months (healthy group, ages 18 to 65)
You will not qualify if you...
- History of chronic pain conditions such as fibromyalgia, irritable bowel syndrome, temporomandibular dysfunction, or migraines
- Neurological or sensory dysfunction especially in upper limbs
- History of chronic musculoskeletal pain including arthritis or chronic low back pain
- Contraindications to cold application such as Raynaud's disease or diabetes
- Current or long-term use of pain medication or antidepressants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Pressure Pain Threshold Testing
Duration - About 30 minutes in one day
Participants complete a Pressure Pain Threshold (PPT) test-retest protocol involving measurements at the wrist and elbow with an electronic digital algometer.
1 visit (in-person)
Conditioned Pain Modulation Testing
Duration - 1.5 hours on a separate day
Participants undergo Conditioned Pain Modulation (CPM) testing, including immersion of the uninvolved hand in ice water and repeated PPT measurements to assess pain modulation.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
The Hashemite University, Department of Physical Therapy; Community Rehabilitation Center Clinics
Zarqa, Zarqa Governorate, Jordan, 13115
Actively Recruiting
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Research Team
A
Ahmad Muhsen, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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Published Research Related To This Trial
Reliability of Pressure Pain Threshold (PPT) and Conditioned Pain Modulation (CPM) in Participants with and without Chronic Shoulder Pain.
Paraskevi Bilika, Panagiotis Kalamatas-Mavrikas, Nikolaos Vasilis...
https://pubmed.ncbi.nlm.nih.gov/39273758