The inter- and intra-individual variance in descending pain modulation evoked by different conditioning stimuli in healthy men.
Yuka Oono, Hongling Nie, Renata Lima Matos...
https://pubmed.ncbi.nlm.nih.gov/29913755/Actively Recruiting
Led by The Hashemite University · Updated on 2026-06-26
38
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying how people with and without tennis elbow lateral elbow tendinopathy sense pressure pain and how their bodys natural pain reduction system works after exposure to cold. This study evaluates pressure pain threshold PPT reliability and the duration of conditioned pain modulation CPM after-effect using a handheld device and a cold-pressor task. The goal is to improve assessments and treatments for musculoskeletal pain conditions. Participants complete questionnaires about demographics, tennis elbow symptoms, and physical activity, then undergo a PPT test where pressure is gradually increased on spots near the elbow and wrist until pain is reported. To assess CPM, one hand is placed in ice water for 2 minutes, and PPT is measured before, during, and at multiple times after immersion to track changes in pain sensitivity and the time for pain perception to return to baseline. During the study, participants attend two separate sessions one lasting about 30 minutes for PPT testing and another lasting about 1.5 hours for CPM testing. Researchers use standardized testing sites and repeated measurements at set intervals. Data is coded and securely stored. The findings focus on PPT measurement reliability and the timing of pain modulation effects, contributing to better future pain management strategies.
CONDITIONS
Assessment of Pressure Pain Threshold (PPT) and Conditioned Pain Modulation (CPM) After Effect in Patients With and Without Tennis Elbow (TE)
A
Ahmad Muhsen, PhD
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The Hashemite University
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - About 30 minutes in one day
Participants complete questionnaires, then undergo pressure pain threshold testing using a handheld device that applies pressure to spots near the elbow and wrist. Three measurements are taken at several time points.
1 session
Duration - About 1.5 hours on a separate day
Participants immerse one hand in ice water for 2 minutes while pressure pain threshold is measured before, during, and multiple times after cold exposure to assess pain sensitivity changes and duration.
1 session
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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Yuka Oono, Hongling Nie, Renata Lima Matos...
https://pubmed.ncbi.nlm.nih.gov/29913755/Paraskevi Bilika, Panagiotis Kalamatas-Mavrikas, Nikolaos Vasilis...
https://pubmed.ncbi.nlm.nih.gov/39273758/The Hashemite University
Lead Sponsor