Actively Recruiting
Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy
Led by Cairo University · Updated on 2025-01-23
22
Participants Needed
2
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to assess Pro-Resolution Mediator levels during non-surgical periodontal therapy in individuals with Stage III and IV periodontitis, comparing them to healthy subjects. Periodontitis, a chronic inflammatory condition affecting tooth-supporting tissues, can lead to tooth loss and systemic complications. Understanding the role of pro-resolving lipid mediators in inflammation resolution may offer insights into therapeutic benefits associated with these mediators.
CONDITIONS
Official Title
Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients above 18 years old
- Interdental clinical attachment loss at site of greatest loss 5 mm or extending to middle third of the root
- Interdental clinical attachment loss at site of greatest loss 8 mm or extending to apical third of the root
- Probing depth 6 mm
- Vertical bone loss 3 mm
- Tooth loss due to periodontitis of 4 teeth for Stage III
- Tooth loss due to periodontitis of 5 teeth for Stage IV
- Furcation involvement Class II or III, moderate ridge defect
- Systemically healthy patients (healthy group)
- Patients aged between 16 and 80 years (healthy group)
- Patients with at least 20 teeth (healthy group)
- Less than 10% bleeding sites with probing depths 3 mm (healthy group)
- Absence of erythema and oedema (healthy group)
You will not qualify if you...
- Pregnancy or lactation
- Smoking more than 20 cigarettes daily
- Immuno-inflammatory conditions of the skin and oral mucosa
- Systemic conditions affecting bone turnover and periodontal health (e.g., endocrine and connective tissue diseases, bisphosphonate therapy, gastrointestinal diseases related to nutrition and mineral metabolism)
- Periodontal or orthodontic treatment within 6 months before study start
- Use of anti-inflammatory and antimicrobial agents within 3 months before sampling
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Faculty of Dentistry-Cairo University
Manial, Cairo Governorate, Egypt, 12311
Actively Recruiting
2
faculty of dentistry Cairo university
Cairo, Egypt
Actively Recruiting
Research Team
H
Husam Ghazi Alharbi, Master Degree
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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