Measuring Pro-Resolution Mediator Levels in Adults with Advanced Periodontitis Before and After Non-Surgical Periodontal Therapy Compared to Healthy Adults

What this Trial Is About

Researchers are evaluating the levels of pro-resolution mediators, which are substances that help resolve inflammation, in people with Stage III and IV periodontitis compared to healthy individuals. Periodontitis is a chronic inflammatory disease that slowly damages the tissues supporting teeth, possibly leading to tooth loss and other health problems. This study aims to improve understanding of how these mediators affect inflammation and healing during periodontal therapy. The study involves a non-surgical periodontal therapy called professional mechanical plaque control, which includes motivating patients to improve oral hygiene, removing plaque and calculus professionally, adjusting faulty dental restorations, and teaching brushing and interdental cleaning techniques. Participants include those with advanced periodontitis and a control group of healthy patients. The design compares levels of pro-resolution mediators before and after treatment in the periodontitis group and against the healthy controls. Participants will have their gums checked and fluid samples taken at multiple times before treatment, one day, one month, and three months after therapy. Researchers will measure inflammatory markers like lipoxin A4 and other clinical signs such as probing depth, bleeding on probing, plaque levels, attachment loss, and the number of healed pockets. The study uses randomized assignment and triple masking to ensure unbiased results and will last from the start of treatment through three months post-treatment.

Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy