Actively Recruiting
Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation
Led by University Hospital, Toulouse · Updated on 2025-09-22
56
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Liver transplantation is a key treatment for patients with end-stage liver disease and other serious conditions, but it carries a high risk of bleeding. Managing blood clotting during surgery is complex because standard tests often do not reflect the true bleeding risk. This research evaluates whether using the Quantra device, which provides rapid bedside blood clotting tests, can better guide blood transfusions and reduce bleeding compared to conventional methods. Participants will be randomly assigned to one of two groups: one group will have transfusions guided by the Quantra Qstat device, which measures clot formation at specific surgery stages and during bleeding events; the other group will follow transfusion decisions based on routine coagulation tests. The Quantra method uses a novel sonorheometry technique with ready-to-use cartridges, aiming to improve clot assessment without mechanical contact. During the study, patients will be closely monitored through blood tests and clinical assessments throughout their liver transplantation surgery. Researchers will measure the amount of fresh frozen plasma transfused during the operation as the main outcome. The study will track transfusion needs, bleeding control, and the overall management of coagulation. Participants will be followed from before surgery until bleeding is controlled, with detailed monitoring to assess the effectiveness of the Quantra-guided transfusion approach.
CONDITIONS
Brief Title
Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older
- Patients with end-stage liver disease undergoing liver transplantation
- Individuals affiliated with or beneficiaries of a social security scheme
- Free and informed written consent obtained from the patient or an authorized representative
You will not qualify if you...
- Multi-organ transplantation
- Congenital haemostasis disorders such as haemophilia
- Patients under legal protection such as guardianship or curatorship
- Pregnant or breastfeeding women
- Patients already enrolled in another interventional study targeting bleeding or transfusion reduction
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of the liver transplantation surgery
Participants undergo liver transplantation surgery where transfusion management is guided either by a Quantra®-based transfusion algorithm or a conventional transfusion algorithm. Quantra Qstat® analyses are performed before incision, at the end of native liver dissection, and after unclamping of venous anastomoses, with additional analyses during bleeding as needed.
1 surgical procedure visit
Trial Site Locations
Total: 1 location
1
Toulouse University Hospital
Toulouse, France, 31059
Actively Recruiting
Research Team
G
Guillaume PORTA BONETE, Md
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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