Study of Quantra-Guided Blood Transfusion During Liver Transplant Surgery Compared to Conventional Methods

What this Trial Is About

Liver transplantation is a key treatment for patients with end-stage liver disease and other serious conditions, but it carries a high risk of bleeding. Managing blood clotting during surgery is complex because standard tests often do not reflect the true bleeding risk. This research evaluates whether using the Quantra device, which provides rapid bedside blood clotting tests, can better guide blood transfusions and reduce bleeding compared to conventional methods. Participants will be randomly assigned to one of two groups one group will have transfusions guided by the Quantra Qstat device, which measures clot formation at specific surgery stages and during bleeding events the other group will follow transfusion decisions based on routine coagulation tests. The Quantra method uses a novel sonorheometry technique with ready-to-use cartridges, aiming to improve clot assessment without mechanical contact. During the study, patients will be closely monitored through blood tests and clinical assessments throughout their liver transplantation surgery. Researchers will measure the amount of fresh frozen plasma transfused during the operation as the main outcome. The study will track transfusion needs, bleeding control, and the overall management of coagulation. Participants will be followed from before surgery until bleeding is controlled, with detailed monitoring to assess the effectiveness of the Quantra-guided transfusion approach.

Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation