Actively Recruiting
Assessment of Remote Approaches for Identification of Autonomic Dysfunction Among Survivors of Leukemia and Lymphoma
Led by St. Jude Children's Research Hospital · Updated on 2026-04-23
188
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study seeks to determine if diagnosing cardiac autonomic dysfunction (AD) can be done remotely with the same accuracy as in-person testing. If so, the identification of AD could happen sooner, facilitating remote studies of the condition and potentially reducing the risk of illness. Childhood cancer survivors, particularly survivors of acute lymphoblastic leukemia (ALL) and Hodgkins's lymphoma (HL), appear to be at increased risk for AD. Primary Objectives: * To determine the sensitivity and specificity of heart rate variability (HRV), measured remotely with biosensor technology (Actigraph LEAP), compared to in-person assessment using the Ewing battery as the reference standard to identify cardiac autonomic dysfunction (AD) among survivors of leukemia and lymphoma. * To determine the sensitivity and specificity of the Composite Autonomic Symptom Scale 31 (COMPASS31) compared to the Ewing battery to identify AD among leukemia and lymphoma survivors.
CONDITIONS
Official Title
Assessment of Remote Approaches for Identification of Autonomic Dysfunction Among Survivors of Leukemia and Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants enrolled in St. Jude Lifetime Cohort (SJLIFE) over 18 years old
- Diagnosed with acute lymphoblastic leukemia (ALL), Hodgkin's lymphoma (HL), or non-Hodgkin's lymphoma (Non-HL)
- Not currently taking beta-blocker medications
You will not qualify if you...
- Unable to speak, read, or understand English
- Unable to follow instructions to complete the Ewing battery
- Have acute heart failure with new or worsening symptoms like shortness of breath, swelling, or lung congestion
- Women who are currently pregnant
AI-Screening
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Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
K
Kirsten K Ness, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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