Actively Recruiting
Assessment of Respiratory Drive and Inspiratory Effort Across Pressure Support Levels in Patients After Major Abdominal Surgery
Led by Mahidol University · Updated on 2025-11-18
40
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
Sponsors
M
Mahidol University
Lead Sponsor
S
Siriraj Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This physiological observational study will assess respiratory drive and inspiratory effort across varying levels of pressure support ventilation (PSV) in adult surgical ICU (SICU) patients after major abdominal surgery. By using non-invasive bedside indices (airway occlusion pressure at 100 ms after the onset of inspiration \[P0.1\], maximum negative occlusion pressure \[Pocc\], and pressure muscle index \[PMI\]), we aim to quantify how patients adapt to changes in ventilatory support and determine patterns of under- and over-assistance. Findings may inform optimal titration of PSV to reduce complications and improve clinical outcomes.
CONDITIONS
Official Title
Assessment of Respiratory Drive and Inspiratory Effort Across Pressure Support Levels in Patients After Major Abdominal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (≥18 years) admitted to the surgical ICU
- Recent major abdominal surgery requiring postoperative ICU care
- Receiving invasive mechanical ventilation in pressure support ventilation (PSV) mode at enrollment
- Duration of invasive mechanical ventilation greater than 48 hours
- Clinically stable with no plan for extubation within 6 hours, defined by respiratory rate <35 breaths/min, SpO2 ≥90%, heart rate <140 bpm, no visible accessory muscle use, hemodynamically stable without vasopressor escalation during past hour
- Able to tolerate short-term PSV adjustments as per protocol
You will not qualify if you...
- Known neuromuscular disease affecting respiratory muscle function
- Hemodynamic instability requiring escalation of vasopressor support
- Severe hypoxemic respiratory failure requiring PEEP >10 cmH2O or FiO2 >60%
- Deep sedation (Richmond Agitation-Sedation Scale score < -3) or ongoing neuromuscular blockade
- History of chronic obstructive pulmonary disease (COPD) or other obstructive lung disease
AI-Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Medicine, Siriraj Hospital, Mahidol University
Bangkok, Bangkoknoi, Thailand, 10700
Actively Recruiting
Research Team
N
Nuanprae Kitisin, MD
CONTACT
N
Nattaya Raykateeraroj, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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