Study to Understand How Perinephric Fat Thickness Affects Kidney Health After Living Donor Nephrectomy Research on Blood Pressure and Kidney Function Changes in Living Kidney Donors

What this Trial Is About

Researchers are investigating whether the thickness of perirenal fat PRAT is a marker of visceral obesity and how it may affect kidney function and blood pressure in living kidney donors. This observational study focuses on adults aged 18 and older who are scheduled for kidney donation surgery within six months. The goal is to improve future care for managing blood pressure and obesity in these donors by comparing PRAT characteristics between those with low and high PRAT thickness and examining related kidney outcomes. Participants will be grouped based on their PRAT measurement and body mass index BMI into either a non-obese or obese group. Samples of blood, urine, and perinephric fat tissue will be collected during the study, including during the kidney removal surgery. The study includes a screening visit, a pre-surgery visit, the day of surgery, and a follow-up visit about six months after donation. Optional 18-hour ambulatory blood pressure monitoring ABPM may be performed at some visits. Participants will have their medical history, medications, vital signs, laboratory tests, and imaging data reviewed up to one year before and six months after surgery. Blood and urine samples will be collected for research at multiple visits. Study assessments include blood pressure measurements, weight, height, BMI calculation, and inflammatory markers in the fat tissue. Adverse events will be monitored throughout the study. The total observation period covers from screening until six months post-donation.

Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy