Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
NCT06474169

Assessment of T-cell Response and In-vitro Proof-of-concept of T-cell Engineering in Chronic ESKD Patients.

Led by Centre Hospitalier Régional d'Orléans · Updated on 2025-12-30

100

Participants Needed

1

Research Sites

104 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is a comparative, prospective, non-interventional study to evaluate immune response in patients with chronic kidney disease. The primary objective is to define immunodeficiency (phenotype and function of T cells) in patients with end-stage kidney disease. The second objective is to provide an in-vitro proof-of-concept of T-cell engineering in the context of end-stage kidney disease. The study population was patients with chronic kidney disease.

CONDITIONS

Official Title

Assessment of T-cell Response and In-vitro Proof-of-concept of T-cell Engineering in Chronic ESKD Patients.

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Male or female aged 18 years or older
  • Informed consent given without objection to participation
Not Eligible

You will not qualify if you...

  • Chronic progressive infections
  • Prior organ transplantation, including bone marrow transplantation
  • Treatment with immunosuppressive agents (such as Rituximab, Eculizumab, Tacrolimus, Ciclosporin, Cellcept, or Imurel) within 2 years before inclusion
  • Participant under guardianship, curatorship, or deprived of liberty
  • Pregnant or breastfeeding women

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Center Hospitalier Universitaire d'Orléans

Orléans, France, 45067

Actively Recruiting

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Research Team

M

Manon DEKEYSER, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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