Evaluating Transcranial Alternating Current Stimulation for Cognitive Problems in Adults with Inflammatory Demyelinating Diseases of the Central Nervous System

What this Trial Is About

Researchers are investigating idiopathic inflammatory demyelinating diseases IIDDs of the central nervous system, such as multiple sclerosis and neuromyelitis optica spectrum disease. The study aims to understand the brain imaging and electrical activity patterns in these conditions and how they relate to symptoms. It also explores the potential of transcranial electrical stimulation as a non-invasive therapy to relieve clinical symptoms and improve personalized treatment outcomes. Participants will be randomly assigned to one of two groups one group will receive active transcranial electrical stimulation using the Spanish Neuroelectrics StarStim 32 device, while the other group will receive a placebo stimulation using the same equipment and procedures. This treatment period lasts 5 days, with evaluations conducted during and after the treatment phase to assess effects on disability and cognitive function. During the study, participants will undergo various assessments including the Expanded Disability Status Scale EDSS, Symbol Digit Modalities Test SDMT, and Alzheimers disease assessment scale-cog ADAS-cog at the 5-day treatment point and one month after treatment ends. Additional cognitive and mood tests will also be performed. Researchers will monitor symptoms and any adverse effects daily during treatment. The total participation involves treatment and follow-up assessments to evaluate clinical improvements and safety.

Assessment of Transcranial Alternating Current Stimulation's Clinical Efficacy in Treating Cognitive Impairment of Idiopathic Inflammatory Demyelinating Diseases