Actively Recruiting
Assessment of Venous Return During Volume Expansion: a Prospective Observational Study
Led by Università Politecnica delle Marche · Updated on 2026-03-30
45
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
According to Guyton's model of venous return, the fluids that effectively increase cardiac output are those that, once administered, increase the vascular stressed volume, thereby increasing the mean systemic filling pressure (Pms) without increasing the central venous pressure (CVP). In this way, since the gradient between Pms and CVP increases, venous return-and consequently cardiac output-also increases. In cases where physiologically ineffective fluids are administered, the situation arises in which, in addition to increasing the stressed volume and thus Pms, CVP also increases. As a result, the gradient between Pms and CVP remains unchanged, and cardiac output does not increase. The hypothesis is that only a portion of the fluids administered during volume expansion are actually effective in increasing the gradient between Pms and CVP.
CONDITIONS
Official Title
Assessment of Venous Return During Volume Expansion: a Prospective Observational Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Critically ill patients admitted to the intensive care unit
- Invasive or minimally invasive hemodynamic monitoring
- Clinical indication for volume expansion with 500 mL of crystalloids
You will not qualify if you...
- Suspected or confirmed pregnancy
- Severe aortic stenosis or regurgitation
- Severe mitral stenosis or regurgitation
- History of peripheral arterial disease
- Clinical contraindications to the supine position
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
AOU delle Marche
Ancona, Italy, 60123
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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