Actively Recruiting
Assessment of Venous Return During Volume Expansion: a Prospective Observational Study
Led by Università Politecnica delle Marche · Updated on 2026-03-30
45
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how fluids affect heart function in critically ill patients who need volume expansion. The study focuses on how fluids increase the mean systemic filling pressure (Pms) and central venous pressure (CVP), which together influence venous return and cardiac output. The goal is to understand why only some of the fluids given actually improve heart function by increasing the pressure difference between Pms and CVP. The study involves a fluid challenge where 500 mL of crystalloid fluid is given to patients who already have invasive or minimally invasive hemodynamic monitoring. The mean systemic filling pressure is measured using a brief blood flow interruption technique with a blood pressure cuff on the arm. Measurements of Pms, CVP, and cardiac index are taken before, during, and after fluid administration at specific intervals corresponding to 150 mL, 250 mL, 500 mL infused, and one hour after completion. Participants are critically ill adults admitted to the intensive care unit who need volume expansion. During the study, continuous monitoring of cardiac function and pressures will be done. Researchers will evaluate changes in the venous return gradient, cardiac index, and other hemodynamic measures over time. The study aims to classify patients as fluid responders based on changes in stroke volume. This observational study will help improve understanding of fluid effectiveness in critical care settings.
CONDITIONS
Brief Title
Assessment of Venous Return During Volume Expansion: a Prospective Observational Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Critically ill patients admitted to the intensive care unit
- Invasive or minimally invasive hemodynamic monitoring
- Clinical indication for volume expansion with 500 mL of crystalloids
- Age 18 years or older
You will not qualify if you...
- Suspected or confirmed pregnancy
- Severe aortic stenosis or regurgitation
- Severe mitral stenosis or regurgitation
- History of peripheral arterial disease
- Clinical contraindications to the supine position
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 1 hour
Participants receive a fluid challenge of 500 mL of crystalloids as per clinical indication. Hemodynamic measurements including mean systemic filling pressure, central venous pressure, and cardiac index are taken at baseline and at specified intervals during and after the fluid infusion.
1 treatment visit (in-person)
Trial Site Locations
Total: 1 location
1
AOU delle Marche
Ancona, Italy, 60123
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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