Actively Recruiting
Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise
Led by AdventHealth Translational Research Institute · Updated on 2026-03-27
70
Participants Needed
2
Research Sites
237 weeks
Total Duration
On this page
Sponsors
A
AdventHealth Translational Research Institute
Lead Sponsor
P
Pennington Biomedical Research Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin sensitivity in men and women.
CONDITIONS
Official Title
Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and pre-menopausal women
- Age 18 to 45 years
- Body mass index (BMI) between 30.0 and 40.0 kg/m2
- Women not using hormonal contraception must use specified birth control methods or abstain
- Able to speak and understand English
- Sedentary lifestyle with no more than 1 day per week of structured endurance or resistance exercise in the past year
- Willing to be randomized to study groups
- Willing to follow all study procedures
- Signed informed consent and HIPAA authorization
You will not qualify if you...
- Unstable body weight (> ±5%) in the last 3 months
- Significant recent changes in diet quality or physical activity
- Weight over 396 pounds (180 kg)
- Diagnosis of Type 1 or Type 2 diabetes
- Fasting blood glucose ≥126 mg/dL or HbA1c ≥6.5%
- Blood pressure over 140/90 mmHg
- History of serious cardiovascular conditions or recent heart events
- Anemia with low hemoglobin or hematocrit
- Kidney disease or abnormal liver enzymes
- Serious digestive disorders
- Chronic infections or immune diseases requiring treatment
- Current or past eating disorders
- Bleeding or clotting disorders
- Chronic obstructive pulmonary disease (COPD)
- High triglycerides or LDL cholesterol
- Recent blood donation or planned donation during study
- Recent autoimmune treatment
- Excessive alcohol consumption or recent smoking
- Night shift work recently or planned
- Allergy to local anesthetics
- Thyroid disorders not stable
- Prior bariatric or obesity surgery
- Recent cancer treatment
- Psychiatric conditions affecting study adherence
- Pregnancy, recent postpartum or lactation, or planning pregnancy
- Polycystic ovarian syndrome
- Metabolic bone disease
- Recent hospitalization for COVID-19
- Partial or full hysterectomy
- Unwillingness to provide biospecimens or undergo microdialysis
- MRI contraindications or inability to tolerate MRI
- Positive toxicology screen
- Use of certain medications including recent changes or chronic treatments that interfere with study
- Any condition compromising safety or data integrity per investigator judgment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
AdventHealth Translational Research Institute
Orlando, Florida, United States, 32804
Actively Recruiting
2
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70808
Not Yet Recruiting
Research Team
R
Recruitment Department
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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