Actively Recruiting
Assessments in Patients With Muscular Pathology and in Control Subjects : The ActiLiège Next Study
Led by Centre Hospitalier Universitaire de Liege · Updated on 2025-05-20
300
Participants Needed
8
Research Sites
294 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire de Liege
Lead Sponsor
S
SYSNAV
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of the ActiLiège Next study is to collect longitudinal data from patients and control subjects using a wearable magneto-inertial device. By collecting natural history data in various neuromuscular disorders (Duchenne Muscular Dystrophy, Fascioscapulohumeral Muscular Dystrophy, Myotonic Dystrophy 1, Charcot-Marie-Tooth, Centronuclear Myopathy, Congenital Muscular Dystrophy), we aim to validate digital outcome measures to continuously assess motor function in real-life.
CONDITIONS
Official Title
Assessments in Patients With Muscular Pathology and in Control Subjects : The ActiLiège Next Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Genetically confirmed diagnosis of DMD, FSHD, DM1, CMT, FKRP mutations, or confirmed CNM by muscle biopsy
- FSHD, DM1, CMT, and CNM patients must be ambulant or in transition
- DM1 and CMT patients must have sensori-motor signs on physical exam
- Patients with DMD, CNM under 20 years old
- Patients with FSHD, CMT, and DM1 between 5 and 80 years old
- Patients with FKRP mutations older than 2 years
- Non-ambulant DMD patients able to remain seated in an armchair or wheelchair for at least one hour
- DMD patients treated with corticosteroids for at least 6 months or started corticosteroids at baseline (except patients under 4)
- Signed informed consent by patient or guardian
- Control subjects ambulant boys and girls under 20 years old
- Signed informed consent by control subject or guardian
You will not qualify if you...
- Patients with severe cognitive disorders limiting understanding of exercises
- Patients with surgery or trauma to upper or lower limbs within 6 months (ambulant patients)
- Chronic or acute neurological, endocrine, infectious, allergic, or inflammatory disease within 3 weeks before inclusion
- Patients enrolled in another interventional clinical trial
- DMD patients in transition not receiving corticosteroids
- Control subjects with surgery or trauma to limbs within 6 months
- Elite athletes at the national level
- Control subjects with chronic or acute muscular, neurological, infectious, or inflammatory disease within 3 weeks before inclusion
- Control subjects with orthopedic, neuromuscular, or neurological conditions affecting walking quality
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
CHR de la Citadelle
Liège, Belgium, 4000
Actively Recruiting
2
Fakultni nemocnice v Motole
Prague, Czechia
Active, Not Recruiting
3
Galaa Military Medical Complex
Cairo, Egypt
Active, Not Recruiting
4
Semmelweis University 2nd Department of Paediatrics
Budapest, Hungary
Active, Not Recruiting
5
Warsaw Medical University Hospital, Department of Neurology
Warsaw, Poland
Active, Not Recruiting
6
Pediatric Neurology Clinic, Clinical Hospital of Psychiatry "Prof. Dr. Al. Obregia"
Bucharest, Romania, 041914
Actively Recruiting
7
National Clinical Hospital for Children Neurohabilitation "Dr Nicolae Robanescu"
Bucharest, Romania
Active, Not Recruiting
8
University Children's Hospital, Department for Pediatric Neurology
Ljubljana, Slovenia
Active, Not Recruiting
Research Team
C
Charline DUBOIS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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