How Assisted Reproductive Technologies Influence Pregnancy and Newborn Outcomes A Multicenter Study Comparing Singleton and Multiple Pregnancies

What this Trial Is About

This research aims to understand how different assisted reproductive technology ART methods affect pregnancy and newborn outcomes in individuals with single or multiple pregnancies. The study focuses on whether ART pregnancies have higher risks of small for gestational age babies, fetal growth restriction, preeclampsia, stillbirth, and placental or umbilical cord abnormalities compared to spontaneous pregnancies. It also looks at how specific ART factors like fertilization type, embryo stage at transfer, and ovarian stimulation protocols relate to these outcomes. Participants include pregnant individuals aged 18 or older attending routine first-trimester ultrasounds between 11 and 14 weeks gestation. Detailed information about medical history, ART procedures, and pregnancy progress will be collected, including ultrasound assessments of fetal growth, Doppler studies, and placental features. Outcomes such as birth weight, gestational age, mode of delivery, and complications will be recorded. The study compares ART conceived pregnancies to naturally conceived ones, adjusting for factors like maternal age, BMI, parity, and smoking. Throughout pregnancy, participants will undergo regular prenatal evaluations to monitor fetal growth, placental and umbilical cord structure, and any complications such as preeclampsia or stillbirth. Data will be entered into secure electronic records, and statistical analyses will explore associations between ART parameters and perinatal outcomes. The study aims to improve clinical care and counseling for those using fertility treatments by better understanding these relationships.

Association of Assisted Reproductive Technologies Parameters With the Perinatal Outcome