Study of the Link Between Lung Pressure and Lung Water in Adults with Acute Respiratory Distress Syndrome Using Transpulmonary and Esophageal Pressure Monitoring

What this Trial Is About

Researchers are studying patients with acute respiratory distress syndrome ARDS who are intubated and usually treated with protective ventilation to limit airway pressures. The study focuses on evaluating the relationship between driving transpulmonary pressure, which better reflects lung stress than airway pressure alone, and extravascular lung water, an indicator of lung edema caused by ventilator-induced lung injury VILI. This observational study involves patients monitored with transpulmonary thermodilution devices and esophageal pressure monitoring to estimate pleural pressure. The study tracks changes in transpulmonary driving pressure and its association with extravascular lung water and pulmonary vascular permeability. Various secondary outcomes include correlations with ICU mortality and the influence of patient positioning on lung pressures. Participants will be observed from inclusion until hospital discharge, up to 60 days. During this time, researchers will monitor lung water levels, lung pressures, vascular permeability, and mortality outcomes. The study aims to gather detailed physiological data to understand how ventilator pressures relate to lung injury in ARDS. No experimental treatments are administered instead, patient data is collected and analyzed.

Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS