Actively Recruiting
Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS
Led by Bicetre Hospital · Updated on 2025-02-11
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with acute respiratory distress syndrome (ARDS) who are intubated and usually treated with protective ventilation to limit airway pressures. The study focuses on evaluating the relationship between driving transpulmonary pressure, which better reflects lung stress than airway pressure alone, and extravascular lung water, an indicator of lung edema caused by ventilator-induced lung injury (VILI). This observational study involves patients monitored with transpulmonary thermodilution devices and esophageal pressure monitoring to estimate pleural pressure. The study tracks changes in transpulmonary driving pressure and its association with extravascular lung water and pulmonary vascular permeability. Various secondary outcomes include correlations with ICU mortality and the influence of patient positioning on lung pressures. Participants will be observed from inclusion until hospital discharge, up to 60 days. During this time, researchers will monitor lung water levels, lung pressures, vascular permeability, and mortality outcomes. The study aims to gather detailed physiological data to understand how ventilator pressures relate to lung injury in ARDS. No experimental treatments are administered; instead, patient data is collected and analyzed.
CONDITIONS
Brief Title
Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute respiratory distress syndrome (ARDS)
- Monitoring with a transpulmonary thermodilution device
- Esophageal pressure monitoring
You will not qualify if you...
- Legal protection measures
- Pregnancy
- Contra-indications of esophageal catheter such as esophageal varicose or severe coagulopathy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From inclusion up to hospital discharge (maximum 60 days)
Participants are observed to assess the association between transpulmonary driving pressure and lung water and other respiratory parameters during their hospital stay.
Ongoing assessments during hospital stay
Trial Site Locations
Total: 1 location
1
Medical Intensive Care Unit, Bicêtre Hospital
Le Kremlin-Bicêtre, France
Actively Recruiting
Research Team
T
Tài Pham, MD, PhD.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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